自拟眩晕2号方联合吴茱萸敷贴治疗阴阳两虚型原发性高血压疗效观察  

Clinical observation on self-designed xuanyun fang No.2 combined with fructus evodiae application for primary hypertension with deficiency of yin and yang

作　　者：李颖 裴雯 陈海燕 黄桢 张婷 朱卉 季晓霞 李雯斌 沈亦彦 LI Ying;PEI Wen;CHEN Haiyan;HUANG Zhen;ZHANG Ting;ZHU Hui;JI Xiaoxia;LI Wenbin;SHEN Yiyan(Department of Chinese Medicine for Cardiovascular Disease,Shanghai Jing’an District Hospital of Chinese Medicine Comprehensive Treatment,Shanghai 200072,China)

机构地区：[1]上海市静安区中医医院心血管病中医综合治疗科

出　　处：《安徽医药》2020年第3期579-582,共4页Anhui Medical and Pharmaceutical Journal

基　　金：上海市卫计委上海市中医药发展办公室中医优势病种培育项目(zybz-2017035)

摘　　要：目的探讨眩晕2号方联合吴茱萸敷贴治疗阴阳两虚型原发性高血压疗效观察。方法将2015年1月至2017年12月上海市静安区中医医院收治的90例阴阳两虚型原发性高血压病人遵循完全随机化法,按照就诊顺序编号获得随机数并进行排秩,分为治疗组和对照组,各45例。对照组给予常规西医降压治疗,治疗组在此基础上给予眩晕2号方联合吴茱萸敷贴治疗,两组疗程均为12周。比较两组病人的中医证候评分、中医证候疗效、血压控制及不良反应。结果两组中医证候评分,治疗组:治疗前(22.43±2.67)分,治疗后(5.76±2.71)分,有显著下降(t=29.39,P<0.001),对照组:治疗前(21.90±1.43)分,治疗后(9.79±2.85)分,有显著下降(t=25.48,P<0.001),治疗组的下降幅度明显大于对照组(t=6.87,P<0.001);治疗组的中医证候疗效[显效24例(53.3%),有效18例(40.0%),无效3例(6.7%)]显著优于对照组[显效11例(24.5%),有效20例(44.4%),无效14例(31.1%)](P<0.05);治疗组收缩压:治疗前(157.24±23.48)mmHg,治疗后(130.07±13.91)mmHg,较前显著下降(t=3.89,P<0.001),舒张压:治疗前(102.53±18.71)mmHg,治疗后(79.73±12.05)mmHg,较前显著下降(t=4.19,P<0.001),对照组收缩压:治疗前(159.35±27.63)mmHg,治疗后(139.52±15.69)mmHg,较前显著下降(t=6.87,P<0.001),舒张压:治疗前(103.06±20.76)mmHg,治疗后(88.69±13.53)mmHg,较前显著下降(t=6.69,P<0.001),治疗组收缩压、舒张压均显著低于对照组(t=3.32,P=0.001;t=3.02,P=0.003);两组治疗期间均无明显不良反应。结论在西医治疗基础上,联合眩晕2号方内服和吴茱萸敷贴治疗阴阳两虚型原发性高血压安全有效,在中医证候评分、中医证候疗效、血压控制方面均优于西医降压治疗,值得临床推广应用。Objective To explore clinical effect of Xuanyun Fang No.2 combined with fructus evodiae application for primary hypertension with deficiency of yin and yang.Methods From January 2015 to December 2017,90 cases of hypertension with Yin Yang deficiency were treated in Jing’an District Hospital of TCM in Shanghai,according to the order of visit,the random number was obtained and ranked.The patients were divided into treatment group and control group,each with 45 cases.The control group(n=45)was treated with conventional western medicine for hypertension management,and the treatment group(n=45)was treated with Xuanyun Fang No.2 combined with fructus evodiae application on the basis of control group.All the treatment courses were 12 weeks.The TCM syndromes score,effect of TCM syndromes,blood pressure control and adverse reactions in two groups were observed and compared.Results In the treatment group,(22.43±2.67)points before treatment and(5.76±2.71)points after treatment were significantly decreased(t=29.39,P<0.001).In the control group,(21.90±1.43)points before treatment and(9.79±2.85)points after treatment were significantly decreased(t=25.48,P<0.001),and treatment group has more remarkable decrease than those of control group(t=6.87,P<0.001).The curative effect of TCM syndromes in treatment group[24 cases significantly worked(53.3%),18 cases worked(40.0%),3 cases not worked(6.7%)],was significantly better than that in control group[11 cases significantly worked(24.5%),20 cases worked(44.4%),14 cases not worked(31.1%)](P<0.05).In the treatment group,systolic blood pressure was(157.24±23.48)mmHg before treatment,(130.07±13.91)mmHg after treatment,significantly lower than before(t=3.89,P<0.001).Diastolic blood pressure was(102.53±18.71)mmHg before treatment,(79.73±12.05)mmHg after treatment,significantly lower than before(t=4.19,P<0.001).In the control group,systolic blood pressure was(159.35±27.63)mmHg before treatment,(139.52±15.69)mmHg after treatment,significantly lower than before(t=6.87,P<0.001)diast

关 键 词：高血压/中药疗法 阴阳两虚 吴茱萸 穴位贴敷法 氯沙坦 眩晕2号方 

分 类 号：R259[医药卫生—中西医结合]