儿童药物不良反应1103例分析  

Analysis of adverse drug reactions in 1 103 children

作　　者：王干一 夏旭东[1] 彭亚丽 杨雪[1] 陈世伟 WANG Ganyi;XIA Xudong;PENG Yali;YANG Xue;CHEN Shiwen(Author Affiliation:Center for ADR Monitoring of Henan,Zhengzhou,Henan 450008,China)

机构地区：[1]河南省食品药品评价中心

出　　处：《安徽医药》2020年第3期627-630,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的分析1103例儿童用药不良反应发生的特征,为临床合理的规避儿童用药风险提供理论依据和参考。方法采用回顾性分析方法,对2018年度河南省药品不良反应监测中心所提供的1103例儿童不良反应数据进行统计分析。结果在1103份报告中,男性698例,占总数的63.30%;男女比例为1.72∶1。1岁以下病儿发生不良反应例数最多,为392例,占总数的35.54%。药物不良反应涉及药品以抗微生物药为主,出现315例次,占比28.56%。涉及给药剂型最多的为注射剂类,出现741例次,占比67.18%。给药途径出现例次最多的是静脉滴注,出现734例次,占比66.55%。皮肤及其附件损害是主要累及的系统/器官,频次为613例,占比40.79%。报告类型一般的病儿994例,占比90.1%。对病儿进行对症治疗后,痊愈和好转病儿1089例,占比98.73%。结论1103例儿童药物不良反应中,1岁以下儿童占比较高,且注射剂类药品占比高,提示医务人员在临床工作中要规范用药、合理用药,对于低龄儿童用药更需慎重。Objective To analysis the characteristics and regularity of pediatric adverse drug reactions(ADR),in order to provide theoretical basis and reference for children clinical medication.Methods In retrospective study,1103 pediatric ADR cases collected from ADR Center in 2018 were analyzed statistically.Results Among 1103 pediatric ADR cases,698 cases were male(63.30%),the ratio of men to women was 1.72 to 1.The incidence of ADR in patient age under one year old was the highest(35.54%),about 392 cases.ADR were mainly related to antimicrobial drugs,which occurred 315 times,accounting for 28.56%.Injections were the most frequently used forms of drug delivery,with 741 cases(67.18%).The most frequent route of administration was intravenous drip,734 times,accounting for 66.55%.The lesion of skin and its appendages were the main system/organ involved,the frequency was 613 cases,accounting for 40.79%.994 patients(90.1%)reported general types.After symptomatic treatment,1089 patients recovered and improved,accounting for 98.73%.Conclusion Among the ADR of 1103 children,the proportion of children under one year old is higher,and injections accounted for a higher proportion,which suggested that medical staff should standardize and rational drug use in clinical work,and be more cautious in the use of drugs for young children.

关 键 词：药物毒性 药物警戒性 药物副反应报告系统 儿童 

分 类 号：R95[医药卫生—药学]