黄芪及当归改善化疗后骨髓抑制的分子机制研究进展  

Advances in molecular mechanism of milkvetch root and Chinese angelica to improve myelosuppression after chemotherapy

作　　者：丁欢[1] 吴承杰 潘娅岚 徐桂华[1] 杨敏[1] 史旭芹 王庆[1] DING Huan;WU Chengjie;PAN Yalan;XU Guihua;YANG Min;SHI Xuqin;WANG Qing(College of Nursing,Nanjing University of Chinese Medicine,Jiangsu Province,Nanjing210023,China;the First School of Clinical Medicine,Nanjing University of Chinese Medicine,Jiangsu Province,Nanjing210023,China;College of Pharmacy,Nanjing University of Chinese Medicine,Jiangsu Province,Nanjing210023,China)

机构地区：[1]南京中医药大学护理学院,江苏南京210023 [2]南京中医药大学第一临床医学院,江苏南京210023 [3]南京中医药大学药学院,江苏南京210023

出　　处：《中国医药导报》2020年第5期23-26,共4页China Medical Herald

基　　金：国家自然科学基金资助项目（81603257）

摘　　要：骨髓抑制是化疗后的常见毒副作用,主要与损伤造血干细胞与造血微环境有关。黄芪、当归具有补益气血、扶正补虚的功效,临床常用于改善骨髓抑制。药理研究发现,二者有效成分可通过促进造血细胞增殖、分化而改善化疗后的骨髓抑制,具体机制与多条通路有关,但尚未被阐明,影响进一步的临床应用与推广。本文针对黄芪及当归改善骨髓微环境相关分子机制做出归纳总结,以期为补气血中药改善骨髓抑制的分子机制研究拓展思路,为推广黄芪及当归改善骨髓抑制的临床应用奠定基础。Myelosuppression is a common toxic and side effect after chemotherapy,mainly related to injury of hematopoietic stem cells and hemopoietic microenvironment.Milkvetch root and Chinese angelica have the functions of benefiting qi and blood,strengthening and supplementing deficiency,and are often used to improve myelosuppression.Pharmacological studies have found that the effective components of the two drugs can improve the myelosuppression after chemotherapy by promoting the proliferation and differentiation of hemopoietic stem cells.The specific mechanism is related to multiple pathways,but it has not been clarified yet,affecting further clinical application and promotion.This paper summarizes the molecular mechanism of milkvetch root and Chinese angelica to improve the microenvironment of bone marrow,so as to expand the research idea of the molecular mechanism of traditional Chinese medicine benefiting qi and blood to improve myelosuppression,and lays a foundation for the promotion of milkvetch root and Chinese angelica to improve the clinical application of myelosuppression.

关 键 词：黄芪 当归 造血干细胞 骨髓抑制 造血微环境 

分 类 号：R273[医药卫生—中西医结合]