血清GDF-15水平与慢性阻塞性肺疾病患者肺动脉压力的相关性  

Correlation between serum level of GDF-15 and pulmonary artery pressure in patients with chronic obstructive pulmonary disease

作　　者：张娟 杨和银[2] 胡育英[2] 王怀振[1] ZHANG Juan;YANG Heyin;HU Yuying;WANG Huaizhen(Department of Respiratory Medicine,the First People′s Hospital of Kashgar,Xinjiang Uygur Autonomous Region,Kashgar844000,China;Department of Cardiology,the First People′s Hospital of Kashgar,Xinjiang Uygur Autonomous Region,Kashgar844000,China)

机构地区：[1]新疆维吾尔自治区喀什地区第一人民医院呼吸内科,新疆喀什844000 [2]新疆维吾尔自治区喀什地区第一人民医院心血管内科,新疆喀什844000

出　　处：《中国医药导报》2020年第5期113-116,共4页China Medical Herald

基　　金：国家中医药管理局国家中医临床研究基地业务建设科研专项项目（JDZX2015239）

摘　　要：目的探讨血清生长分化因子-15(GDF-15)水平与慢性阻塞性肺疾病(COPD)患者肺动脉压力的相关性。方法选取2016年1月~2019年1月新疆维吾尔自治区喀什地区第一人民医院(以下简称“我院”)收治的112例COPD患者作为研究组。根据有无肺动脉高压,分为无肺动脉高压组(36例)和合并肺动脉高压组(76例)。合并肺动脉高压组患者根据肺动脉收缩压(sPAP)分为轻度组(24例)、中度组(31例)、重度组(21例)。并选取同期我院60名健康体检者作为对照组。检测血清GDF-15和脑钠肽(BNP)水平,分析患者血清GDF-15水平与sPAP、BNP的相关性。结果无肺动脉高压组及合并肺动脉高压组血清GDF-15、BNP水平均显著高于对照组,且合并肺动脉高压组显著高于无肺动脉高压组(P<0.05)。中度组和重度组血清sPAP、GDF-15及BNP水平均显著高于轻度组,且重度组高于中度组(P<0.05)。COPD患者血清GDF-15水平与sPAP、BNP均呈正相关(r=0.507、0.350,P=0.001、0.029)。结论GDF-15在COPD合并肺动脉高压患者的血清中明显升高,且与患者sPAP、BNP呈正相关。Objective To investigate the correlation between serum level of growth differentiation factor-15(GDF-15)and pulmonary artery pressure in patients with chronic obstructive pulmonary disease(COPD).Methods A total of 112 patients with COPD admitted to First People′s Hospital of Kashgar(“our hospital”for short)from January 2016 to January 2019 were selected as the study group.According to whether have hypertension or not,the patients were divided into non-pulmonary hypertension group(36 cases)and combined pulmonary hypertension group(76 cases).The patients combined pulmonary hypertension were divided into mild group(24 cases),moderate group(31 cases)and severe group(21 cases)according to pulmonary systolic pressure(sPAP).A total of 60 healthy people from our hospital during the same period were selected as the control group.The serum levels of GDF-15 and brain natriuretic peptide(BNP)were detected,while the correlation between serum levels GDF-15 and sPAP and BNP were analyzed.Results Serum GDF-15 and BNP levels in the non-pulmonary hypertension group and the combined pulmonary hypertension group were significantly higher than those in the control group,and the combined pulmonary hypertension group was significantly higher than the non-pulmonary hypertension group(P<0.05).The levels of serum sPAP,GDF-15 and BNP in the moderate and severe groups were significantly higher than those in the mild group,and the severe group was higher than the moderate group(P<0.05).The serum GDF-15 levels were positively correlated with sPAP and BNP in COPD patients(r=0.507,0.350,P=0.001,0.029).Conclusion GDF-15 is significantly increased in the serum of COPD patients combined pulmonary hypertension,and it is positively correlated with sPAP and BNP.

关 键 词：慢性阻塞性肺疾病 生长分化因子-15 肺动脉高压 

分 类 号：R56[医药卫生—呼吸系统]