自拟益气活血祛瘀汤治疗腰椎间盘突出症术后综合征的临床研究  

Clinical study on self-made Yiqi Huoxue Quyu Decoction in the treatment of postoperative syndrome of lumbar disc herniation

作　　者：龚箭 高迎庆[1] 龚艳红 GONG Jian;GAO Yingqing;GONG Yanhong(Department of Orthopaedics,Tieling Central Hospital,Liaoning Province,Tieling112000,China;Department of Pharmacy,Tieling Central Hospital,Liaoning Province,Tieling112000,China)

机构地区：[1]辽宁省铁岭市中心医院骨科,辽宁铁岭112000 [2]辽宁省铁岭市中心医院药剂科,辽宁铁岭112000

出　　处：《中国医药导报》2020年第5期129-132,共4页China Medical Herald

基　　金：辽宁省自然科学基金项目（2015202105）

摘　　要：目的探讨自拟益气活血祛瘀汤治疗腰椎间盘突出症(LDH)术后综合征的临床效果。方法选取2017年1月~2019年3月铁岭市中心医院收治的LDH术后综合征患者103例,根据随机数字表法将患者分为对照组(51例)和研究组(52例),对照组给予常规治疗,研究组在对照组的基础上给予自拟益气活血祛瘀汤治疗,两组均治疗4周。比较两组临床疗效、炎性因子、疼痛视觉模拟评分(VAS)、Oswestry功能障碍指数(ODI)评分、中医症状积分及不良反应。结果治疗4周后,研究组临床总有效率高于对照组(P<0.05)。两组治疗后血清白介素(IL)-1β、IL-6、肿瘤坏死因子-α水平均低于治疗前,且研究组低于对照组(P<0.05)。两组治疗后VAS、ODI评分和中医症状积分均低于治疗前,且研究组低于对照组(P<0.05)。两组均未出现严重的不良反应。结论自拟益气活血祛瘀汤治疗LDH术后综合征,可有效改善临床症状,疗效确切,降低炎性因子水平,且用药安全性好,临床应用价值较高。Objective To explore clinical effect of self-made Yiqi Huoxue Quyu Decoction in the treatment of postoperative syndrome of lumbar disc herniation(LDH).Methods One hundred and three patients with postoperative syndrome of LDH admitted to Tieling Central Hospital from January 2017 to March 2019 were selected,they were divided into control group(51 cases)and study group(52 cases)according to random number table method.Control group was given routine treatment,and study group was given self-made Yiqi Huoxue Quyu Decoction on the basis of control group,two groups were treated for 4 weeks.Clinical efficacy,inflammatory factors,pain visual analogue scale(VAS),Oswestry dysfunction index(ODI),Chinese medicine symptom score and adverse reactions were compared between two groups.Results Total clinical effective rate in study group was significantly higher than that in control group after 4 weeks of treatment(P<0.05).The serum levels of interleukin(IL)-1β,IL-6 and tumor necrosis factor-αin two groups were lower than those before treatment,and the levels in study group were lower than those in control group(P<0.05).After treatment,the scores of VAS,ODI and Chinese medicine symptoms in two groups were lower than those before treatment,and those in study group were lower than those in control group(P<0.05).No serious adverse reactions occurred in both groups.Conclusion Self-made Yiqi Huoxue Quyu Decoction can effectively improve clinical symptoms and reduce the level of inflammatory factors in the treatment of postoperative syndrome of LDH.It has good safety and high clinical application value.

关 键 词：自拟益气活血祛瘀汤 腰椎间盘突出症 术后综合征 临床研究 

分 类 号：R681.5[医药卫生—骨科学]