中药祛银汤对血热证银屑病患者疗效及外周血OPN、VEGF表达的影响  

Efficacy of the Quyin decoction on psoriasis of the Xuere syndrome and expression of OPN and VEGF in peripheral blood

作　　者：王磊 Wang Lei

机构地区：[1]枣庄市市中区人民医院,山东枣庄277100

出　　处：《中医临床研究》2019年第35期104-106,共3页Clinical Journal Of Chinese Medicine

摘　　要：目的:观察中药祛银汤对血热证银屑病患者的临床疗效以及外周血骨桥蛋白(Osteopontin,OPN)、血管内皮生长因子(Vascular Endothelial Growth Factor,VEGF)表达的影响。方法:选取我院在2017年1-12月就诊治疗的40例血热证银屑病患者,并将其设定为实验组,对照组选取我院健康志愿者及健康医护人员共40例,其中实验组采用中药祛银汤进行治疗,观察实验组患者治疗前后的皮损面积和皮损严重程度,检测实验组患者治疗前后外周血中OPN、VEGF的表达情况,并与对照组正常人群进行比较。结果:患者服用中药祛银汤治疗56 d后,患者口渴、便秘、尿黄及心思不定症状有明显改善,患者治疗前外周血中OPN与VEGF的数据明显高于对照组健康志愿者,经治疗后,实验组患者外周血中的OPN与VEGF数据明显下降,但仍高于对照组外周血数据,患者PASI评分治疗前后为(16.27±4.38)分,(7.97±3.39)分。与治疗前对比,差异具有统计学意义(t=2.391,P<0.05)。结论:采用中药祛银汤治疗银屑病有明显临床效果,改善患者中医症状,降低外周血OPN与VEGF水平。Objective:To observe efficacy of the Quyin decoction(祛银汤)on psoriasis of the Xuere syndrome(血热证)and its effect of expression of OPN and VEGF in peripheral blood.Methods:From January to December 2017,40 cases were selected as the experimental group were given the Quyin decoction;and 40 healthy people were selected as the control group.Results:After 56 days,in the experimental group,the clinical symptoms were significantly improved,and the OPN and VEGF data in the peripheral blood were significantly decreased,but higher than the control group.The PASI score was(16.27±4.38)points and(7.97±3.39)points before and after treatment.The difference between the two groups was statistically significant(t=2.391,P<0.05).Conclusion:The Quyin decoction on psoriasis of the Xuere syndrome shows good effects,can improve expression of OPN and VEGF in peripheral blood.

关 键 词：中药祛银汤 血热症银屑病 外周血骨桥蛋白 血管内皮生长因子 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]