腋臭症发病机制研究进展  

A rewiew on pathogenesis of axillary osmidrosis

作　　者：高伟玲 王英 师雅 杨才德[2] Gao Weiling

机构地区：[1]陕西省安康市汉滨区第一医院,陕西安康725000 [2]兰州大学第一医院东岗院区,甘肃兰州730020

出　　处：《中医临床研究》2019年第35期129-131,共3页Clinical Journal Of Chinese Medicine

摘　　要：腋臭症是临床常见病,其症状对患者无直接损伤,但其产生的气味严重影响患者日常人际交往,严重者甚至影响心理健康,本文复习近年来腋臭症发病机制文献,从病因及发病机制角度出发,发现腋臭的味道主要是由尸胺和腐胺所产生,其病因主要与遗传、内分泌、汗腺组织等直接相关,腋臭相关基因ABCC11和ABCC11基因编码的多药耐药相关蛋白8(MRP8)的炎症和内化双重作用可能是腋臭产生的原因,性激素、顶泌汗腺和载脂蛋白D(ApolipoproteinD,ApoD),可能是腋臭发生的重要相关生物条件。对腋臭症发病机制研究可为其治疗提供新思路及新靶点,对腋臭症发病机制仍需进一步研究。Axillary osmidrosis is a common clinical disease.Its symptoms have no direct damage to patients,but its odor seriously affects the daily interpersonal communication of patients,and even affects the mental health of patients.This paper reviews the literature on the pathogenesis of axillary osmidrosis in recent years.From the perspective of etiology and pathogenesis,it is found that the odor of axillary osmidrosis mainly caused by cadaverine.Inflammation and internalization of MDR-related protein 8 encoded by axillary osmidrosis related genes ABCC11 and ABCC11 may be the cause of axillary osmidrosis.Sex hormone,apocrine sweat gland and apoD protein may be the important correlations of axillary osmidrosis.biological conditions.The study on the pathogenesis of axillary osmidrosis can provide new ideas and targets for its treatment.The pathogenesis of axillary osmidrosis still needs further study.

关 键 词：腋臭 ABCC11 多药耐药相关蛋白8 因果律 研究进展 

分 类 号：R322.913[医药卫生—人体解剖和组织胚胎学]