衣康酸生物学功能的研究进展  

Recent Progress in Biological Functions of Itaconic Acid

作　　者：朱鑫[1] ZHU Xin(College of Animal Science and Veterinary Medicine,Shenyang Agricultural University,Shenyang 110866,China)

机构地区：[1]沈阳农业大学畜牧兽医学院

出　　处：《动物营养学报》2020年第3期998-1002,共5页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：辽宁省科技厅项目(201601113);沈阳农业大学博士科研启动基金项目(880416011)

摘　　要：衣康酸是聚合物产业的基础化工产品之一,通过微生物发酵方式实现可再生原材料的生产。哺乳动物体内的衣康酸生物合成途径直到最近才被揭示出来,即三羧酸(TCA)循环中间产物顺乌头酸在顺乌头酸脱羧酶(CAD)/免疫响应基因1蛋白(IRG1)作用下生成衣康酸。生成的衣康酸具有抑制磷酸果糖激酶2(PFK2)和琥珀酸脱氢酶(SDH)活性的作用。此外,衣康酸也具有抗菌、抗肿瘤、抗炎、抗氧化、抗病毒、营养代谢调控等生物学功能。因此,本文主要就衣康酸的生物学功能最新进展进行综述。Itaconic acid is one of the basic chemicals for the polymer industry,which can be produced using microbes on the basis of renewable raw materials.Until recently,itaconic acid biosynthesis has just been found in mammalian cells,in which itaconic acid is produced by the decarboxylation of cis-aconictic acid,a tricarboxylic acid(TCA)cycle intermediate,by cis-aconictic acid decarboxylase(CAD)/immune-responsive gene 1 protein(IRG1).Itaconic acid has inhibitory effects on phosphofructokinase 2(PFK2)and succinate dehydrogenase(SDH).In addition,itaconic acid also plays important roles in anti-microbial,anti-cancer,anti-inflammatory,anti-oxidative,anti-viral and nutrition regulation activities,attracting more attention from researchers for its biological functions.The present review summarizes the research process of biological functions of itaconic acid.

关 键 词：衣康酸 免疫调节 营养调控 肿瘤 氧化应激 抗菌活性 

分 类 号：S816.7[农业科学—饲料科学]