补充双歧杆菌四联活菌片对糖尿病性骨质疏松患者骨代谢指标影响的研究  

Study on the changes in levels of bone metabolic markers in diabetic osteoporosis patients after supplementation of Tetralogy of Viable Bifidobacterium tablet

作　　者：宋永坡[1] 郭英欣 李嘉萍[1] SONG Yongpo;GUO Yingxin;LI Jiaping(Department of Endocrinology,Jilin Central Hospital,Jilin 132000;Jilin People′s Hospital,Jilin 132000,China)

机构地区：[1]吉林市中心医院内分泌科,吉林吉林市132000 [2]吉林市人民医院,吉林吉林市132000

出　　处：《中国骨质疏松杂志》2020年第2期291-293,共3页Chinese Journal of Osteoporosis

摘　　要：目的通过观察2型糖尿病性骨质疏松患者补充双歧杆菌四联活菌片后骨代谢指标的变化,探讨补充益生菌是否能改善骨代谢标志物及骨密度。方法选取2016年1月至2017年12月在我院内分泌科门诊检查或住院的2型糖尿病性骨质疏松患者200例,随机分为对照组(100名)与实验组(100名)。对照组患者采取常规补充钙剂及维生素D治疗;实验组患者在给予补充钙剂及维生素D治疗基础上加用双歧杆菌四联活菌片治疗。于治疗后3个月、6个月、12个月后观察患者骨钙素、尿钙肌酐比、总1型胶原氨基端延长肽、维生素D和骨密度(12个月测1次)的变化。结果补充双歧杆菌四联活菌后骨钙素水平明显升高,骨密度明显升高,差异有统计学意义。补充维生素D后维生素D水平明显升高,差异有统计学意义。结论补充双歧杆菌四联活菌片后,通过升高2型糖尿病性骨质疏松患者的骨钙素水平改善了骨密度。Objective To investigate the changes in levels of bone metabolic markers in type 2 diabetic osteoporosis patients after supplementation of Tetralogy of Viable Bifidobacterium tablet,and to explore whether supplementation of probiotics could improve bone metabolism and bone mineral density. Methods 200 patients with type 2 diabetic osteoporosis who were examined or hospitalized in the Endocrinology Department of our hospital from January 2016 to December 2017 were randomly divided into control group(100) and experimental group(100). Patients in the control group were given routine calcium and vitamin D treatment;patients in the experimental group were given calcium supplement and vitamin D plus bifidobacterium tetragenous viable bacteria tablets. Patients’ osteocalcin,urinary calcium-creatinine ratio,total type Ⅰ collagen amino-terminal extension of peptides,vitamin D and bone mineral density were observed after 3 months,6 months and 12 months of treatment(bone mineral density was measured after 12 months).Results The level of osteocalcin and bone mineral density increased significantly after supplementation of live Bifidobacterium tetrad,with statistical difference. After vitamin D supplementation,the level of vitamin D increased significantly with statistical difference.Conclusion Supplementation of Tetralogy of Viable Bifidobacterium tablet could improve bone mineral density in type 2 diabetic osteoporosis patients.

关 键 词：骨质疏松 糖尿病 益生菌 骨代谢标志物 骨钙素 维生素K 

分 类 号：R681[医药卫生—骨科学]