益气活血方改善2型糖尿病血管内皮功能及踝肱指数的临床研究  

Clinical Study on Qi-invigorating Blood-activating Prescription in Improving Vascular Endothelial Function and Ankle-brachial Indexes in Diabetic Patients

作　　者：张文雅[1] 唐红[1] 杨华[1] 宋怡萍[1] 连真[1] 曾娟花[1] ZHANG Wenya;TANG Hong;YANG Hua;SONG Yiping;LIAN Zhen;ZENG Juanhua(Longhua Hospital Shanghai University of TCM,Shanghai 200032,China)

机构地区：[1]上海中医药大学附属龙华医院

出　　处：《西部中医药》2019年第12期58-61,共4页Western Journal of Traditional Chinese Medicine

基　　金：浦东新区中医学科人才项目(编号PDZYXK-3-2014004);上海市“科技创新行动计划”临床医学领域项目(编号17401970200)

摘　　要：目的:观察益气活血方治疗血瘀证2型糖尿病的临床疗效。方法:将119例患者随机分为观察组60例、对照组59例,观察组服用益气活血方,1剂/d,水煎早晚餐后分服。对照组早餐后服用拜阿司匹林肠溶片,100 mg/次,1次/d。2组均连续治疗12周。观察2组临床疗效及治疗后血管内皮功能、踝肱指数(ankle-brachial indexes,ABI)改善情况。结果:总有效率观察组为73.33%(44/60),对照组为52.54%(31/59),2组比较差异有统计学意义(P<0.05)。临床症状评分及ABI治疗前后2组组内比较,差异有统计学意义(P<0.05);治疗后2组组间比较差异有统计学意义(P<0.05)。与治疗前相比,内皮素(endothelin,ET)水平2组均下降,组内比较差异有统计学意义(P<0.05);治疗后2组组间比较,组内比较差异无统计学意义(P>0.05)。血管内皮生长因子(vascular endothelial growth factor,VEGF)水平观察组有所下降,差异有统计学意义(P<0.05),对照组无明显变化,差异无统计学意义(P>0.05);治疗后2组间比较,差异有统计学意义(P<0.05)。结论:益气活血方治疗2型糖尿病临床疗效满意,有改善临床症状和微循环的作用。Objective:To observe clinical effects of Qi-invigorating blood-activating prescription in the treatment for type two diabetes mellitus of blood stagnation pattern.Methods:All 119 patients were randomized into60 cases of the observation group and 59 cases of the control group,the observation group accepted Qi-invigorating blood-activating prescription,one dose each day,taking after breakfast and supper after water decocted.The control group took Bayaspirin enteric-coated tablets after the breakfast,100 mg each time,once each day.Both groups were treated for 12 weeks consecutively.To observe clinical effects,the improvements of vascular endothelial function and ankle-brachial indexes(ABI)after treating.Results:Total effective rate of the observation group was 73.33%(44/60),higher than 52.54%(31/59)of the control group,and the difference had statistical meaning(P<0.05).The difference had statistical meaning in clinical symptom scores and ABI within two groups before and after treating(P<0.05);the difference could be found between both groups after treating(P<0.05).Compared with before treating,endothelin(ET)level reduced in both groups,and the difference showed statistical meaning(P<0.05);the difference had no statistical meaning beween both groups after treating(P>0.05).Vascular endothelial growth factor(VEGF)level reduced in the observation group,and the differe n ce had statistical meaning(P<0.05),no obvious changes happened in the control group,and the difference had no statistical meaning(P>0.05);the difference could be found between both groups after treating(P<0.05).Conclusion:Qi-invigorating blood-activating prescription could obtain satisfactory effects in the treatment for DM,and it could improve clinical symptoms and microcirculation.

关 键 词：2型糖尿病 血瘀证 益气活血 血管内皮 踝肱比 中医药 临床疗效 

分 类 号：R255.4[医药卫生—中医内科学]