布地奈德对嗜酸性粒细胞性支气管炎患者炎性因子及肺功能的影响研究  

Study on the effect of budesonide on inflammatory factors and pulmonary function in patients with eosinophilic bronchitis

作　　者：吴冬霞 曾峰 WU Dong-xia;ZENG Feng(Qingyuan People's Hospital,Qingyuan 511518,China)

机构地区：[1]清远市人民医院,511518

出　　处：《中国实用医药》2020年第4期86-88,共3页China Practical Medicine

摘　　要：目的探讨布地奈德对嗜酸性粒细胞性支气管炎(EB)患者炎性因子及肺功能的影响。方法 86例嗜酸性粒细胞性支气管炎患者作为研究对象,按随机数字表法分为对照组和观察组,各43例。对照组采用常规抗菌药物治疗,观察组采用布地奈德治疗。对比两组患者治疗后炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-4、IL-5、IL-8]及肺功能指标[用力肺活量(FVC)、第一秒用力呼气容积(FEV1)、FEV1/FVC、残气量(RV)、最高呼气流速(PEF)、残气量与肺总量比值(RV/TLC)]变化情况。结果治疗后,观察组患者的TNF-α(121.52±30.45)ng/L高于对照组的(86.25±25.14)ng/L,IL-4(8.87±2.36)ng/L、IL-5(11.03±3.27)ng/L、IL-8(40.36±6.97)ng/L均显著低于对照组的(24.52±11.74)、(31.42±16.21)、(46.25±6.74)ng/L,差异均有统计学意义(P<0.05)。治疗后,观察组患者的FVC(2.95±0.25)L、FEV1(2.13±0.25)L、FEV1/FVC(77.21±4.05)%、PEF(311.19±82.47)ml/s均高于对照组的(2.35±0.55)L、(1.81±0.42)L、(61.23±4.05)%、(269.21±82.63)ml/s, RV(1.51±0.41)L、RV/TLC(31.03±2.64)%均低于对照组的(2.31±0.42)L、(42.07±2.67)%,差异均具有统计学意义(P<0.05)。结论采用布地奈德治疗嗜酸性粒细胞性支气管炎患者临床效果显著,治疗后炎性因子水平显著降低,肺功能指标改善明显。Objective To discuss the effect of budesonide on inflammatory factors and pulmonary function in patients with eosinophilic bronchitis(EB). Methods A total of 86 patients with eosinophilic bronchitis as study subjects were divided into control group and observation group by random number table method, with 43 cases in each group. The control group was treated with conventional antibiotics, and the observation group was treated with budesonide. The changes of inflammatory factors [tumor necrosis factor-α(TNF-α), interleukin(IL)-4, IL-5, IL-8] and pulmonary function indicators [forced vital capacity(FVC), forced expiratory volume in the first second(FEV1), FEV1/FVC, residual volume(RV), peak expiratory flow rate(PEF), RV/total lung capacity(TLC)] after treatment were compared between the two groups. Results After treatment, the TNF-α(121.52±30.45) ng/L in the observation group was higher than(86.25±25.14) ng/L in the control group, and IL-4(8.87±2.36) ng/L, IL-5(11.03±3.27) ng/L and IL-8(40.36±6.97) ng/L were significantly lower than(24.52±11.74),(31.42±16.21) and(46.25±6.74)ng/L in the control group. Their difference was statistically significant(P<0.05). After treatment, FVC(2.95±0.25) L, FEV1(2.13±0.25) L, FEV1/FVC(77.21±4.05)% and PEF(311.19±82.47) ml/s in the observation group were higher than(2.35±0.55) L,(1.81±0.42) L,(61.23±4.05)% and(269.21±82.63) ml/s in the control group, and RV(1.51±0.41) L, RV/TLC(31.03±2.64)% were lower than(2.31±0.42) L and(42.07±2.67)% in the control group. Their difference was statistically significant(P<0.05). Conclusion Budesonide shows remarkable clinical effect in the treatment of eosinophilic bronchitis. It can significantly lower the level of inflammatory factors and obviously improved the lung function index.

关 键 词：嗜酸性粒细胞性支气管炎 炎性因子 肺功能 

分 类 号：R562.21[医药卫生—呼吸系统]