魔芋接枝丙烯酸-丙烯酰胺/高岭土复合材料的制备及其释药性能  

Preparation of konjac glucmannan grafted polyacrylic acid-acrylamide/kaolin composites and study on their properties in drug release

作　　者：胡盛 HU Sheng(Hubei Key Laboratory of Biological Resources Protection and Utilization,Hubei Minzu University,Enshi 445000,China;School of Chemical and Environmental Engineering,Hubei Minzu University,Enshi 445000,China)

机构地区：[1]湖北民族大学生物资源保护与利用湖北省重点实验室 [2]湖北民族大学化学与环境工程学院

出　　处：《现代化工》2020年第2期123-127,共5页Modern Chemical Industry

基　　金：国家自然科学基金项目(31460172);恩施州科技计划项目(D20180027);湖北民族学院博士启动基金项目(MY2017B023);生物资源保护与利用湖北省重点实验室开放基金项目(PKLHB1709)

摘　　要：采用溶液聚合法制备魔芋接枝丙烯酸-丙烯酰胺/高岭土复合材料。正交试验分析表明,当高岭土质量为丙烯酸质量的20%、聚合温度为80℃、丙烯酸中和度为70%、聚合时间为90 min、丙烯酰胺与丙烯酸质量比为1∶2时,制备得到的魔芋接枝丙烯酸-丙烯酰胺/高岭土复合材料的吸蒸馏水倍率最高,为506. 2 g/g。以布洛芬为模型药物,研究了魔芋接枝丙烯酸-丙烯酰胺/高岭土复合材料对布洛芬的释药性能,结果表明,载药复合材料在p H=7. 4的缓冲溶液中的累积释药率明显高于在p H=1. 2的溶液中的累积释药率,其对布洛芬的释放机理符合Fickian扩散。红外光谱(FT-IR)分析结果表明,魔芋、丙烯酸、丙烯酰胺、高岭土和布洛芬发生了相互作用,共同参与了接枝聚合反应。Konjac grafted polyacrylic acid-acrylamide/kaolin composite material,a novel superabsorbent composite,is prepared through aqueous solution polymerization method by using konjac glucmannan( KGM),acrylic acid,acrylamide and kaolin as raw materials.The orthogonal test results show that the highest absorbency 506. 2 g·g^-1 can be given by the composite that is prepared under the following conditions: the mass amount of kaolin is 20% that of acrylic acid,polymerization temperature is set at 80℃,the neutralization degree of acrylic acid is 70%,polymerization time is 90 min and the mass ratio of acrylamide to acrylic acid is 1 ∶ 2. Taking ibuprofen as a model drug,the drug releasing properties of the prepared composites are evaluated in the buffer solution with different p H values. The experimental results show that the cumulative drug-releasing rate of the composites in the buffer solution of p H = 7. 4 is significantly higher than that in the solution of p H = 1. 2.The release mechanism of the composites to ibuprofen accords with Fickian diffusion.The results via FT-IR spectra show that the interaction happens among konjac glucmannan,acrylic acid,acrylamide,kaolin and ibuprofen,which all participate in the graft polymerization reaction.

关 键 词：魔芋 高岭土 丙烯酰胺 布洛芬 释药性能 

分 类 号：TB324[一般工业技术—材料科学与工程]