白细胞介素、降钙素原及C-反应蛋白与产妇产褥感染的相关性分析  

Correlation analysis on interleukins,PCT,CRP,and puerperal infection

作　　者：严春华[1] 郑云英[1] 张建果[1] 张媚娜 YAN Chun-Hua;ZHENG Yun-Ying;ZHANG Jian-Guo(Department of Gynecology and Obstetrics,the First Affiliated Hospital of Xiamen University,Xiamen,Fujian 361000,China)

机构地区：[1]厦门大学附属第一医院妇产科,福建厦门361000 [2]福建医科大学附属第一医院妇产科,福建福州350005

出　　处：《中国妇幼保健》2020年第5期803-807,共5页Maternal and Child Health Care of China

基　　金：福建省卫生计生青年科研课题(2017-1-56)

摘　　要：目的探讨分娩后产褥感染患者血清白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、降钙素原(PCT)及C-反应蛋白(CRP)的表达水平,并分析其与产褥感染的关系。方法选取2015年6月-2018年6月在该院分娩并确诊为产褥感染的产妇112例为研究组,另选取同期在该院住院的100例未发生感染的产妇为对照组。通过检测所有产妇生殖道病原体感染情况及血清IL-6、IL-10、PCT、CRP水平,分析其与产褥感染的关系。结果研究组检出支原体感染52例(66.67%),革兰氏阳性菌感染15例(19.23%),革兰氏阴性菌感染11例(14.10%)。分娩前,两组产妇血清IL-6、IL-10、PCT、CRP水平比较,差异无统计学意义(P>0.05)。分娩后24 h,研究组产妇血清IL-6、IL-10、PCT、CRP水平均高于对照组,差异均有统计学意义(均P<0.05);分娩后72 h,研究组产妇血清IL-6、PCT、CRP水平均高于对照组,差异均有统计学意义(均P<0.05);且研究组产妇血清IL-6、IL-10、PCT、CRP水平随感染时间延长而上升(P<0.05),对照组产妇血清IL-6、IL-10、PCT、CRP水平随着时间延长先上升,后下降至分娩前水平(P<0.05)。盆腔腹膜炎患者分娩后72 h的血清IL-6、IL-10、PCT、CRP水平高于子宫内膜及附件炎,子宫内膜及附件炎血清各指标水平高于外阴阴道及宫颈炎。结论产褥感染产妇分娩后血清IL-6、IL-10、PCT、CRP水平明显高于正常产妇分娩后水平,三者与产褥感染的发生、进展密切相关,对早期发现并干预产褥感染具有一定的临床价值。Objective To investigate the expression levels of interleukin-6(IL-6),interleukin-10(IL-10),procalcitonin(PCT)and c-reactive protein(CRP)in patients with puerperal infection after delivery,and to analyze the relationship with the puerperal infection.Methods A total of 112 pregnant women who gave birth in the hospital and were diagnosed with puerperal infection from June 2015 to June 2018 were selected as the researh group,and a total of 100 uninfected pregnant women hospitalized during the same period were selected as the control group.Through the detection of all maternal genital tract pathogens and serum IL-6,IL-10,PCT,CRP levels,the relationship between them and puerperal infection was analyzed.Results There were 52 cases of mycoplasma infection in the study group,accounting for 66.67%,and 15 cases of Gram-positive bacteria infection(19.23%),and 11 cases of Gram-negative bacterial infection(14.10%).There were no significant differences in serum IL-6,IL-10,PCT,and CRP levels between the study group and the control group before delivery(P>0.05).The serum levels of IL-6,IL-10,PCT,and CRP in the study components at 24 hours after delivery were higher than those in the control group,and the differences were statistically significant(P<0.05).The serum IL-6,PCT,and CRP levels of the study components at 72 hours after delivery were higher than those of the control group,and the differences were statistically significant(P<0.05).And the serum levels of IL-6,IL-10,PCT,and CRP in the study group increased with the extension of infection time(P<0.05),and the serum levels of IL-6,IL-10,PCT,and CRP in the control group increased first with time.Then it decreased to the level before delivery(P<0.05).Patients with pelvic peritonitis had serum IL-6,IL-10,PCT,and CRP levels 72 h after delivery,which were higher than those of endometrium and appendicitis.Serum levels of endometrium and accessory inflammation were higher than those of vulvovaginal and cervicitis.Conclusion Serum IL-6,IL-10,PCT and CRP levels of puerperal infectio

关 键 词：产褥感染 白细胞介素-6 白细胞介素-10 降钙素原 C-反应蛋白 剖宫产术后 

分 类 号：R714[医药卫生—妇产科学]