HMGB1/RAGE信号与呼吸系统疾病及其研究进展  

HMGB1/RAGE signal and respiratory diseases and its research progress

作　　者：孙婧怡 孙亚冰[1] 马礼兵[1] Sun Jingyi;Sun Yabing;Ma Libing(Department of Respiratory and Critical Care Medicine,Affiliated Hospital of Guilin Medical University,Guilin 541001,China)

机构地区：[1]桂林医学院附属医院呼吸与危重症医学科,541001

出　　处：《国际呼吸杂志》2020年第3期229-234,共6页International Journal of Respiration

基　　金：国家自然科学基金(81360006、81560007、81760009);广西壮族自治区自然科学基金(2015GXNSFAA139106)。

摘　　要：高迁移率族蛋白1(HMGB1)广泛参与机体各种炎症反应过程,晚期糖基化终产物受体(RAGE)和部分Toll样受体家族是其主要作用受体。已有大量研究证实HMGB1通过RAGE受体途径,可诱导炎症反应、免疫应答、肿瘤发生多种生理病理学效应,参与多种疾病的发生发展。在肺组织中HMGB1有广泛表达,而HMGB1/RAGE信号已被证实参与诸多慢性气道疾病的发病过程。尤其是在哮喘的发生发展过程中,HMGB1/RAGE信号被证实在其中发挥重要作用,但具体机制仍不清。本文初步阐述HMGB1/RAGE在呼吸系统疾病尤其是哮喘发病中的作用及相关研究进展。High mobility group box-1 protein(HMGB1)is widely involved in various inflammatory response processes in the body.The receptor for advanced glycation end-products(RAGE)and some Toll-like receptors are its main receptors.A large number of studies have confirmed that HMGB1 can induce various physiological and pathological effects of inflammatory response,immune response,tumor occurrence through the RAGE receptor pathway,and participate in the occurrence and development of various diseases.HMGB1 is widely expressed in lung tissues,and HMGB1/RAGE signal has been shown to be involved in the pathogenesis of many chronic airway diseases.Especially in the occurrence and development of asthma,HMGB1/RAGE signal has been confirmed to play an important role in it,but the specific mechanism is still unclear.This article preliminarily explains the role of HMGB1/RAGE in respiratory diseases,especially asthma,and related research progress.

关 键 词：HMGB1/RAGE信号 呼吸系统疾病 哮喘 

分 类 号：R5[医药卫生—内科学]