血清骨膜素水平与老年髋部骨折患者骨密度相关性研究  

Correlation between serum periostin level and bone mineral density in elderly patients with hip fractures

作　　者：李江华[1] 李新梅[1] 陈磊[1] 戴毅 李琪[1] LI Jianghua;LI Xinmei;CHEN Lei;DAI Yi;LI Qi(Department of Orthopedics,the First Affiliated Hospital of Shihezi University Medical College,Shihezi 832000;Department of Medical,the First Affiliated Hospital of Shihezi University Medical College,Shihezi 832000,China)

机构地区：[1]石河子大学医学院第一附属医院骨科,新疆石河子832000 [2]石河子大学医学院第一附属医院医务处,新疆石河子832000

出　　处：《中国骨质疏松杂志》2020年第1期59-63,共5页Chinese Journal of Osteoporosis

摘　　要：目的探索老年髋部骨折患者骨膜素(sPostn)水平与骨密度的相关性。方法纳入108例患有骨质疏松性髋部骨折的老年女性和106名年龄不匹配的无骨折女性作为对照。在2 d内骨折后测量其临床特征、骨密度(bone mineral density,BMD)和骨转换标志物(包括sPostn水平)。对于108例患者,检测1年内的随访sPostn水平。结果骨折后sPostn的初始水平显著高于对照组。在整个队列中,sPostn与股骨颈BMD,骨Ⅰ型胶原N-端前肽(PINP)和Ⅰ型胶原交联C-末端肽(β-CTX)相关(P均<0.05)。多变量分析后,sPostn仍然是股骨颈BMD的独立危险因素。骨折后7 d内采样的sPostn从第2天开始急剧增加,然后减少并在360 d保持在略高的水平。sPostn的变化与骨折后第7天β-CTX(P<0.05)和PINP(P<0.05)的变化呈正相关。结论高sPostn水平是老年女性急性髋部骨折患者股骨颈低BMD的独立预测因素。Objective To explore the correlation between periosteal(sPostn)levels and bone mineral density in elderly patients with hip fractures.Methods This study enrolled 108 elderly women with osteoporotic hip fractures and 106 age-matched women without fracture as controls.Clinical features,bone mineral density(BMD),and bone turnover markers including sPostn level were measured in 2 days after fractures.sPostn levels were followed up in 108 patients in 1 year.Results Initial levels of sPostn after fracture were significantly higher in patients than in controls.sPostn was correlated with BMD of the femoral neck(P<0.05),β-isomerized C-terminal crosslinking of type I collagen(β-CTX,P<0.05),and N-terminal procollagen of type I collagen(PINP,P<0.05)in the entire cohort.After multivariate analysis,sPostn remained as an independent risk factor for femoral neck BMD.sPostn acutely increased from day 2 after the fracture sampled within 7 days,and then decreased and maintained at slightly high level in 360 days.The changes of sPostn positively correlated with the variation inβ-CTX(P<0.05)and PINP(P<0.05)at day 7 after fracture.Conclusion High sPostn level is an independent predictor of low femoral neck BMD in elder women with acute hip fractures.

关 键 词：老年人 骨折愈合 髋部骨折 骨质疏松 骨膜素 

分 类 号：R683.3[医药卫生—骨科学]