基于OPG/RANK/RANKL信号轴探讨中医“瘀证”与骨质疏松症之间的关系  

Study on the relationship between TCM blood stasis syndrome and osteoporosis based on OPG/RANK/RANKL signal axis

作　　者：曹盼举 张晓刚 于海洋 秦大平 蒋宜伟 朱晓荣 郭强强 王志鹏 宋敏 赵希云 CAO Panju;ZHANG Xiaogang;YU Haiyang;QIN Daping;JIANG Yiwei;ZHU Xiaorong;GUO Qiangqiang;WANG Zhipeng;SONG Min;ZHAO Xiyun(School of Clinical Medicine,Gansu University of Chinese Medicine,Lanzhou 730000;The Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730000;College of Integration of Traditional Chinese and Western Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学中医临床学院,甘肃兰州730000 [2]甘肃中医药大学附属医院,甘肃兰州730000 [3]甘肃中医药大学中西医结合学院,甘肃兰州730000

出　　处：《中国骨质疏松杂志》2020年第1期114-117,共4页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金(81560780,81760873);甘肃省中医药管理局课题(GZK-2017-17);甘肃中医药大学中青年科研基金项目(ZQ2014-22);甘肃中医药大学教学改革科研项目(230514520202);2019年甘肃省高等学校创新能力提升项目(2019B-107)

摘　　要：近年来,随着中医学的不断发展,中医药在治疗骨质疏松症(osteoporosis,OP)中的应用愈加广泛,然而由于只有单纯的中医理论指导,而缺乏现代科学依据的支撑,故而广受争议。与此同时,OPG/RANK/RANKL信号轴的发现又是现代分子生物学的一大突破。因此,笔者立足于中西医结合的角度,基于中医脏腑亏虚立论,从OPG/RANK/RANKL信号调控机制探讨中医学从“瘀证”论治骨质疏松症的合理性,从而为中医从“瘀”辨治OP以及临床研究提供科学理论依据。In recent years,with the continuous development of traditional Chinese medicine(TCM),the application of TCM in the treatment of osteoporosis(OP)has become more and more widespread.However,due to the simple guidance of TCM theory and the lack of support from modern scientific basis,it is widely disputed.At the same time,the discovery of OPG/RANK/RANKL signal axis is a breakthrough in modern molecular biology.Therefore,in this article,based on the theory of deficiency of viscera and organs of traditional Chinese medicine,the authors explore the rationality of blood stasis in the treatment of OP in traditional Chinese medicine by introducing the mechanism of OPG/RANK/RANKL signal regulation,so as to provide scientific theoretical basis for differentiation and treatment of OP from blood stasis in traditional Chinese medicine and clinical research.

关 键 词：OPG/RANK/RANKL信号轴 瘀证 骨质疏松 中医中药 

分 类 号：R589.5[医药卫生—内分泌] R259[医药卫生—内科学]