经前烦躁障碍症肝气逆证患者的事件相关电位特征研究  

Characteristics of ERPs of Premenstrual Dysphoric Disorder With Invasion of Liver Qi

作　　者：伍盼盼[1] 詹向红[1] 刘永[1] 杨丽萍[1] 赵川[1] Wu Panpan;Zhan Xianghong;Liu Yong;Yang Liping;Zhao Chuan(School of Basic Medicine,Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学基础医学院,郑州450046

出　　处：《世界科学技术-中医药现代化》2019年第11期2485-2490,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家科技部国家重点基础研究发展计划子课题(2011CB505102):从肝论治抑郁症(轻、中度)、经前期综合征(重度,PMDD)探讨肝主疏泄调畅情志的作用机制,负责人:詹向红;国家自然科学基金委员会面上项目(81173148):基于肝疏泄理论探讨情志对衰老进程中认知功能的影响及机制,负责人:詹向红;国家自然科学基金委员会面上项目(81473556):疏肝法对情绪调节不良MCI患者工作记忆影响的机制研究,负责人:詹向红;国家自然科学基金委员会面上项目(81873208):肝失疏泄对正常人群和MCI患者认知功能衰退进程的影响及机制研究,负责人:詹向红。

摘　　要：目的探讨经前烦躁障碍症(Premenstrual Dysphoric Disorder,PMDD)肝气逆证患者神经电生理变化,为PMDD的中医证候增添新内涵。方法采用问卷调查和事件相关电位(ERPs)技术,以在校大学生为被试,结合Go/Nogo范式采集被试脑电,比较PMDD肝气逆证患者(病例组)和正常志愿者(对照组)月经前期、后期的脑电特征。结果①行为数据反映,与对照组比较,PMDD肝气逆证患者命中率低,错报率高,任务表现较差。②脑电数据显示,与对照组比较,PMDD肝气逆证患者月经前期Nogo-N2及Nogo-P3潜伏期较短,且N2波幅较小。结论 PMDD肝气逆证患者月经前期与正常人群相比抑制能力较弱,可能存在不同的认知加工过程。Objective To explore the related biochemical markers of the patients with premenstrual dysphoric disorder(PMDD), in order to increase the understanding of PMDD from the differences in connotation and mechanism between syndromes. Methods The university students were selected as subjects, and they were asked to fill in the questionnaires.Their characteristics of electroneurophysiology were collected by Go/Nogo experimental paradigm with the help of ERPs and Neuroscan. The differences of the characteristics of electroneurophysiology between the invasion of liver qi group and the normal control group were analyzed. Results From the behavior data, there were premenstrual differences in the hit rate and the false positive rate between the invasion of liver qi group and normal control group. The hit rate in the invasion of liver qi group is lower than that in normal control group. The false positive rate in the invasion of liver qi group is higher than that in normal control group. Seen from ERPs, compared with control group, the latency of Nogo-N2 and Nogo-P3 were shorter before menstruation in the invasion of liver qi group and the difference were the marginally significant. And the amplitude of N2 was lower before Menstruation in the invasion of liver qi group. Conclusion In patients with PMDD liver-qi invasion syndrome, the pre-menstrual period is weaker than the normal population, and there may be different cognitive processing.

关 键 词：经前烦躁障碍症 肝气逆证 事件相关电位 Go/Nogo实验范式 

分 类 号：R2-031[医药卫生—中西医结合]