小儿原发性肾病综合征复发的危险因素logistics回归分析  

Logistics regression analysis of the risk factors affecting the recurrence of Primary nephrotic syndrome in children

作　　者：刘钧菲[1] 刘翠华[1] 厉洪江 田明 张书锋[1] 曹广海 魏磊[1] 刘平[1] 李广波 李玉柳 Liu Junfei;Liu Cuihua;Li Hongjiang;Tian Ming;Zhang Shufeng;Cao Guanghai;Wei Lei;Liu Ping;Li Guangbo;Li Yuliu(Department of Renal Rheumatism,Children’s Hospital Affiliated to Zhengzhou University,Henan Children’s Hospital,Zhengzhou Children’s Hospital,Zhengzhou 450000,China)

机构地区：[1]郑州大学附属儿童医院河南省儿童医院郑州儿童医院肾脏风湿科,450000

出　　处：《中国实用医刊》2019年第22期13-16,共4页Chinese Journal of Practical Medicine

基　　金：河南省2016年度科技发展计划(162102310225)。

摘　　要：目的探讨小儿原发性肾病综合征(PNS)复发的危险因素.方法收集2015年1月至2017年12月郑州大学附属儿童医院收治的204例PNS患儿的临床资料,所有患儿出院后进行1~2年随访,按照患儿有无PNS复发,分为复发组(146例)和非复发组(58例),对患儿临床特征、指标等采用单因素分析、多因素Logistics回归分析.结果204例PNS患儿中共146例出现复发,复发率为71.57%;复发组与非复发组在入院时24 h尿蛋白定量、血清IgG、血沉(ESR)、胆固醇水平及水肿程度、缓解时间、有无反复感染、出院后激素应用规范与否、家属PNS护理知识水平比较差异有统计学意义(P<0.05);多因素logistics回归分析显示,初发时24 h尿蛋白定量水平高、胆固醇水平高、首次治疗缓解所需时间长、反复感染、家属PNS护理知识水平低是PNS患儿复发的危险因素(P<0.05).结论临床应重视PNS患儿初诊时24 h尿蛋白定量、胆固醇等指标,要针对性选择合适的治疗方案及疗程,同时应积极防治感染,加强家属疾病护理知识指导,尽可能减少患儿复发.Objective To explore the risk factors affecting the recurrence of primary nephrotic syndrome(PNS)in children.Methods The clinical data of 204 children with PNS admitted to's Hospital Affiliated to Zhengzhou University from January 2015 to December 2017 were collected.All patients were followed up for 1-2 years after discharge.According to PNS recurrence condition in children,they were divided into recurrence group(146 cases)and non-recurrence group(58 cases).Univariate analysis and multivariate logistics regression analysis were performed on clinical features and indexes of children.Results A total of 146 cases were with recurrence among the 204 children with PNS,and the recurrence rate was 71.57%.There were statistically significant differences in 24 h urine protein quantitation,serum IgG,erythrocyte sedimentation rate(ESR),cholesterol levels and edema degree,time required for remission,repeated infection condition,standardized hormonal application after discharge and family PNS nursing knowledge level between recurrence group and non-recurrence group(P<0.05).Multivariate logistics regression analysis showed that high 24 h urine protein quantitation level,high cholesterol level,long time required for first-time treatment remission,repeated infection and low family PNS nursing knowledge level were risk factors for recurrence in children with PNS(P<0.05).Conclusions It is necessary to pay attention to 24 h urine protein quantitation and cholesterol of children with PNS at first diagnosis in clinical,and it is also necessary to select appropriate treatment regimens and courses,actively prevent infections and strengthen family nursing knowledge guidance so as to minimize the recurrence of the disease.

关 键 词：原发性肾病综合征 儿童 复发 Logistics回归分析 

分 类 号：R726.9[医药卫生—儿科]