腺样体肥大儿童血清TNF-αIL-6 s IL-2R水平与肥大程度及预后的关系  

Relationship between Serum TNF-α IL-6 sIL-2R Levels and the Severity and Prognosis of Children with Adenoid Hypertrophy

作　　者：徐亚雄[1] 王远明[1] 杨刚 李楚凌[1] XU Yaxiong;WANG Yuanming;YANG Gang(Dongguan Maternal and Child Health Care Hospital/Dongguan Women's and Children's Hospital,Guangdong Dongguan 523000,China)

机构地区：[1]广东省东莞市妇幼保健院/东莞市妇女儿童医院耳鼻咽喉头颈外科

出　　处：《河北医学》2020年第3期358-362,共5页Hebei Medicine

基　　金：广东省科技计划项目，(编号:2013B0150284)

摘　　要：目的:探究腺样体肥大儿童血清TNF-α、IL-6、sIL-2R水平与肥大程度及预后的关系。方法:回顾性分析2016年8月至2018年8月我院收治100例腺样体肥大患儿相关资料。患儿肥大程度、腺样体再增生率情况分析,比较不同肥大程度患儿血清指标水平,分析三种血清指标与肥大程度相关性,比较不同预后患儿三种血清指标水平,分析三指标对患儿腺样体再增生情况预测价值。结果:100例患儿中Ⅰ度、Ⅱ度、Ⅲ度肥大程度患儿分别36例、32例以及32例,患儿腺样体再增生率为15.00%(15/100),其中Ⅰ度、Ⅱ度以及Ⅲ度肥大程度患儿腺样体再增生分别2例(2.00%)、6例(6.00%)、7例(7.00%),差异比较没有统计学意义(χ^2=4.063,P>0.05);不同肥大程度患儿TNF-α、IL-6、sIL-2R水平大小为Ⅰ度<Ⅱ度<Ⅲ度,不同肥大程度患儿差异比较具有统计学意义(P<0.05);TNF-α、IL-6、sIL-2R等血清学指标与腺样体肥大程度之间关系为正相关(P<0.05);随访期间增生患儿TNF-α、IL-6、sIL-2R水平显著高于未增生患儿(P<0.05);ROC曲线显示,联合诊断AUC(0.896)优于TNF-α、IL-6、sIL-2R单一诊断(0.845,0.814,0.709)。结论:腺样体肥大儿童血清TNF-α、IL-6、sIL-2R水平与患儿腺样体肥大程度关系密切,均可用于预测患儿预后情况,但三指标联合预测价值较好。Objective: To explore relationship between serum TNF-α,IL-6,sIL-2R levels and the severity and prognosis of children with adenoid hypertrophy.Methods:The related data of 100 children with adenoid hypertrophy who were admitted to the hospital between August 2016 and August 2018 were retrospectively analyzed.The severity of hypertrophy and rate of adenoid re-hyperplasia were analyzed.The levels of serum indexes were compared among children with different severities of hypertrophy and different prognosis.The correlation between the three serum indexes and hypertrophy,and their predictive value for adenoid re-hyperplasia were analyzed.Results:Of the 100 children,there were 36,32 and 32 cases with grade I,grade II and grade III hypertrophy,respectively.The rate of adenoid re-hyperplasia was 15.00%(15/100).Among them,there respectively were 2 cases(2.00%),6 cases(6.00%),and 7 cases(7.00%)with adenoid re-hyperplasia(χ^2=4.063,P>0.05).The order of levels of TNF-α,IL-6 and sIL-2R in children with different severities of hypertrophy from low to high was as follows:grade I,grade II and grade III(P<0.05).TNF-α,IL-6 and sIL-2R were positively correlated with the severity of adenoid hypertrophy(P<0.05).During follow-up,levels of TNF-α,IL-6 and sIL-2R in children with hyperplasia were significantly higher than those without(P<0.05).ROC curve analysis showed that the AUC of combined diagnosis(0.896)was better than that of single diagnosis with TNF-α,IL-6 or sIL-2R(0.845,0.814,0.709).Conclusion:The levels of serum TNF-α,IL-6 and sIL-2R are closely related to the severity of adenoid hypertrophy in children.All of them can be applied to predict the prognosis of children but the combined prediction of the three is better.

关 键 词：腺样体肥大儿童 TNF-α IL-6 SIL-2R 

分 类 号：R72[医药卫生—儿科]