产后妇女大脑默认网络异常改变的静息态功能MRI研究  

Abnormalities of the default mode network in postpartum women:a rs-fMRI study

作　　者：吴卓遥 陈慧铀 殷信道[2] 唐文伟[1] 郑金霞[1] WU Zhuoyao;CHEN Huiyou;YIN Xindao;TANG Wenwei;ZHENG Jinxia(Department of Radiology,Women’s Hospital of Nanjing Medical University,Nanjing Maternity and Child Health Care Hospital,Nanjing 210004,China;Department of Radiology,Nanjing First Hospital,Nanjing Medical University,Nanjing 210006)

机构地区：[1]南京医科大学附属妇产医院(南京市妇幼保健院)放射科,江苏南京210004 [2]南京医科大学附属南京医院(南京市第一医院)放射科,江苏南京210006

出　　处：《实用放射学杂志》2020年第2期176-179,共4页Journal of Practical Radiology

基　　金：江苏省妇幼健康科研项目(F201829);南京市卫生科技发展专项资金项目(YKK18162)。

摘　　要：目的探讨产后妇女大脑默认网络的功能连接与产后认知功能下降之间的相关性.方法从21例产后妇女和21例年龄和教育程度相匹配的未生育女性中获得rs-fMRI扫描数据.选择后扣带回作为种子点区域以检测功能连接,然后确定这些变化是否与特定的认知表现相关.结果与未生育女性相比,产后妇女的后扣带回和左内侧前额叶之间的功能连接显著降低.在校正年龄和教育程度后,后扣带回和左内侧前额叶皮层之间的功能连接减少与产后妇女较差的画钟测验(CDT)评分呈正相关(r=0.697,P=0.001).结论产后妇女默认网络区域内的静息态功能连接减少,与产后妇女认知功能受损有关,说明默认网络可以反映产后妇女的认知功能情况,将为产后期潜在的神经病理学机制提供新的见解.Objective To investigate the functional connectivity(FC)pattern of the default mode network(DMN)and its associations with cognitive dysfunction in postpartum women.Methods rs-fMRl data were acquired from 21 postpartum women and 21 age-and education-matched nulliparous women.The posterior cingulate cortex(PCC)was selected as the seed region to detect the FC patterns and then determine whether these changes were associated with specific cognitive performance.Results Compared with the nulliparous women,postpartum women showed significantly decreased FC between the PCC and the left medial prefrontal cortex(mPFC).After correcting for age and education,reduced FC between the PCC and the left mPFC was positively correlated with the poorer clock-rrawing test(CDT)scores in postpartum women(r=0.697,P=0.001).Conclusion The decreased FC within the DMN is related to the impaired cognitive function in postpartum women,the DMN can reflect the cognitive function of postpartum women,and will provide new insights into the underlying neuropathological mechanism of postpartum.

关 键 词：产后妇女 功能连接 默认网络 认知功能下降 静息态功能磁共振成像 

分 类 号：R714.69[医药卫生—妇产科学] R742[医药卫生—临床医学]