Limited therapeutic potential of astrocyte elevated gene-1 transduction in an animal model of Parkinson’s disease  

作　　者：Eunju Leem Sang Ryong Kim 

机构地区：[1]School of Life Sciences,BK21 plus KNU Creative BioResearch Group,Kyungpook National University,Daegu,Korea [2]Brain Science and Engineering Institute,Kyungpook National University,Daegu,Korea

出　　处：《Neural Regeneration Research》2020年第10期1850-1851,共2页中国神经再生研究（英文版）

基　　金：supported by a grant from the National Research Foundation of Korea(NRF-2020R1A2C2007954)

摘　　要：Biological roles of astrocyte elevated gene-1(AEG-1):AEG-1,also known as metadherin,was originally identified as a human immunodeficiency virus-1-and tumor necrosis factor-alpha-inducible gene in human fetal astrocytes.The increase in AEG-1 expression is a well-established and important oncogenic event in various types of human cancer,and its upregulation triggers evasion of cellular apoptosis,metastasis,and invasion in cancer(Emdad at al.,2016;Dhiman et al.,2019).AEG-1 can promote tumor progression via multiple phosphoinositide 3-kinase(PI3K)/protein kinase B(Akt)pathways,contributing to an invasive phenotype and angiogenesis(Emdad at al.,2016;Dhiman et al.,2019).In addition,there is evidence for a functional link between AEG-1 and pro-survival mechanisms in various cancers(Dhiman et al.,2019),suggesting that AEG-1 is a key molecule for oncogenic events in cancer.

关 键 词：ELEVATED al. INVASION 

分 类 号：R651.2[医药卫生—外科学]