Neogenin-loss in neural crest cells results in persistent hyperplastic primary vitreous formation  

作　　者：Sen Lin Wei Liu Chun-Lin Chen Dong Sun Jin-Xia Hu Lei Li Jian Ye Lin Mei Wen-Cheng Xiong 

机构地区：[1]Department of Neuroscience&Regenerative Medicine and Department of Neurology,Augusta University,Augusta,GA 30912,USA [2]Department of Ophthalmology,Daping Hospital,Army Medical Center of PLA,Chongqing,China [3]Department of Neurosciences,School of Medicine,Case Western Reserve University,Cleveland,OH 44106,USA

出　　处：《Journal of Molecular Cell Biology》2020年第1期17-31,共15页分子细胞生物学报（英文版）

摘　　要：Neogenin is a transmembrane receptor critical for multiple cellular processes,including neurogenesis,astrogliogenesis,endochondral bone formation,and iron homeostasis.Here we present evidence that loss of neogenin contributes to pathogenesis of persistent hyperplastic primary vitreous(PHPV)formation,a genetic disorder accounting for^5% of blindness in the USA.Selective loss of neogenin in neural crest cells(as observed in Wntl-Cre;Neofff mice),but not neural stem cells(as observed in GFAP-Cre and Nestin-Cre;Neo^f/f mice),resulted in a dysregulation of neural crest cell migration or delamination,exhibiting features of PHPV-like pathology(e.g.elevated retrolental mass),unclosed retinal fissure,and microphthalmia.These results demonstrate an unrecognized function of neogenin in preventing PHPV pathogenesis,implicating neogenin regulation of neural crest cell delamination/migration and retinal fissure formation as potential underlying mechanisms of PHPV.

关 键 词：NEOGENIN PHPV ocular fissure neural crest cells 

分 类 号：Q25[生物学—细胞生物学]