前列腺切除术围术期出血与临床护理预处理的关系  

Relationship between Perioperative Bleeding in Clinical Nursing Pretreatment

作　　者：陈静[1] 李军[1] 张强[1] Chen Jing;Li Jun;Zhang Qiang(Gansu Cancer Hospital,Lanzhou,730050)

机构地区：[1]甘肃省肿瘤医院,兰州730050

出　　处：《基因组学与应用生物学》2020年第1期290-294,共5页Genomics and Applied Biology

摘　　要：研究护理中术前服用度他雄胺2周减少前列腺内二氢睾酮和前列腺组织血管分布对前列腺术后出血的影响。本研究纳入了83例符合TURP适应症的良性前列腺增生患者。度他雄胺组由40名患者组成,术前两周内接受度他雄胺(0.5 mg/d)治疗;对照组由43名患者组成,术前两周内不接受度他雄胺治疗。根据术前、术后、术后24 h的血清血红蛋白(Hb)和血细胞比容(Hct)水平来评估失血情况。本次研究还探究了药物对留置尿道导管的使用时间、连续盐水膀胱冲洗时间和住院时间的影响。术后和术后1 d平均失血量方面,度他雄胺组低于对照组(ΔHb=(0.65±1.27) g/d L∶(1.16±0.73) g/d L,(1.30±1.00) g/dL∶(1.86±1.05) g/dL,p=0.019,p=0.011;ΔHct=(1.89±3.83)%∶(3.47±2.09)%,(3.69±2.95)%∶(5.39±3.23)%,p=0.016,p=0.011)。此外,在度他雄胺组中,尿道留置导尿管天数((2.95±1.02) d∶(3.92±1.14) d,p=0.000)、连续盐水膀胱冲洗时间((1.81±1.08) d∶(2.36±1.06) d,p=0.016)和TURP后的住院时间((3.95±1.09) d∶(4.76±1.19) d,p=0.001)较小。本研究表明,在TURP术前护理中用度他雄胺进行两周的治疗,可减少术后出血和TURP术后住院时间。这种临床护理预处理可用于减少与TURP相关的手术出血,建议临床使用。In clinical care,the dose of dutasteride was taken 2 weeks before surgery to reduce the distribution of dihydrotestosterone and prostate tissue in the prostate,and to explore the effect of drugs on postoperative bleeding in prostate.This study included 83 patients with benign prostatic hyperplasia who were eligible for TURP indications.The dutasteride group consisted of 40 patients who received dutasteride(0.5 mg/d) within two weeks before surgery;the control group consisted of 43 patients who did not receive dutasteride for two weeks before surgery.Blood loss was assessed according to the decrease in serum hemoglobin(Hb) and hematocrit(Hct) levels before,after and 24 hours after operation.The study also explored the effects of drugs on the duration of indwelling urethral catheters,continuous saline flushing time,and length of hospital stay.In terms of postoperative and postoperative 1 d mean blood loss,the tarosamine group was lower than the control group(ΔHb=(0.65±1.27)g/dL∶(1.16±0.73) g/dL,(1.30±1.00) g/d L∶(1.86±1.05) g/d L,p=0.019,p=0.011;ΔHct=(1.89±3.83)%∶(3.47±2.09)%,(3.69±2.95)%∶(5.39±3.23)%,p=0.016,p=0.011).In addition,in the dutasteride group,days of urethral indwelling catheter((2.95 ±1.02) d ∶(3.92±1.14) d,p=0.000),continuous saline bladder washing time((1.81 ±1.08) d ∶(2.36 ±1.06) d,p=0.016),and the length of stay after TURP((3.95±1.09) d∶(4.76±1.19) d,p=0.001) were smaller.Two weeks of TURP treatment reduced postoperative bleeding and postoperative hospital stay.This pretreatment could be used to reduce the surgical bleeding associated with TURP.

关 键 词：度他雄胺 前列腺增生症 经尿道前列腺切除术 临床护理预处理 

分 类 号：R473.6[医药卫生—护理学]