巴戟天寡糖联合帕罗西汀治疗抑郁症临床评价  

Morinda Officinalis Oligosaccharide Capsule Combined with Paroxetine on Depression

作　　者：曹重阳 韩露[1] 王克[1] 牛静 王冠军[1] CAO Chongyang;HAN Lu;WANG Ke;NIU Jing;WANG Guanjun(Qingdao Municipal Hospital,Qingdao,Shandong,China 266000;Medical College of Qingdao University,Qingdao,Shandong,China 266000)

机构地区：[1]山东省青岛市市立医院,山东青岛266000 [2]青岛大学医学院,山东青岛266000

出　　处：《中国药业》2020年第6期148-150,共3页China Pharmaceuticals

基　　金：山东省科技发展计划项目[2016GGX102063]。

摘　　要：目的 探讨巴戟天寡糖胶囊联合帕罗西汀治疗抑郁症的疗效及对神经递质和炎性因子水平的影响。方法 选取青岛市市立医院2015年2月至2018年12月收治的抑郁症患者143例,按随机数字表法分为对照组(71例)和研究组(72例)。两组患者均予帕罗西汀治疗,研究组患者加用巴戟天寡糖胶囊,均治疗8周。结果 研究组总有效率为70.83%,明显高于对照组的54.93%(P<0.05);治疗后,两组患者的去甲肾上腺素(NE)、5-羟色胺(5-HT)、脑源性神经营养因子(BDNF)水平均明显升高(P<0.05),神经生长因子(NGF)及白细胞介素6(IL-6)、白细胞介素12(IL-12)、肿瘤坏死因子-α(TNF-α)水平均明显降低(P<0.05),且研究组均明显优于对照组(P<0.05);研究组不良反应发生率与对照组相当(20.83%比15.49%,P>0.05)。结论 巴戟天寡糖胶囊联合帕罗西汀治疗抑郁症,可有效改善患者神经内分泌功能和炎性状况。Objective To investigate the efficacy of morinda officinalis oligosaccharide capsule combined with paroxetine in the treatment of depression and its effect on neuroendocrine function and inflammatory factors.Methods A total of 143 patients with depression admitted to Qingdao Municipal Hospital from February 2015 to December 2018 were selected and divided into control group(n=71)and study group(n=72)according to the digital table method.Both groups were treated for 8 weeks.Results The total effective rate of the study group was 70.83%,which was significantly higher than 54.93%of the control group(P<0.05).After treatment,the levels of norepinephrine(NE),5-hydroxytryptamine(5-HT)and brain-derived neurotrophic factor(BDNF)all increased in the two groups(P<0.05),while the levels of nerve growth factor(NGF),interleukin-6(IL-6),interleukin-12(IL-12)and tumor necrosis factor-α(TNF-α)decreased in both groups(P<0.05);the improvement in the study group were better than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(20.83%vs.15.49%,P>0.05).Conclusion Morinda officinalis oligosaccharide capsule combined with paroxetine is effective in the treatment of depression.It can effectively improve the neuroendocrine function and inflammatory status of patients without increasing the incidence of adverse reactions.

关 键 词：巴戟天寡糖 帕罗西汀 抑郁症 临床疗效 神经内分泌功能 炎性因子 

分 类 号：R969.4[医药卫生—药理学] R2-031[医药卫生—药学]