新型冠状病毒(SARS-CoV-2)传播的溯源分析及启示  

A source-seeking analysis and its implication on the transmission of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)

作　　者：王晓钰 崔立[1] WANG Xiao-yu;CUI Li(Shanghai Key Laboratory of Veterinary Biotechnology,Shanghai Jiao Tong University School of Agriculture and Biology,Shanghai 200240,China)

机构地区：[1]上海交通大学农业与生物学院,上海市兽医生物技术重点实验室,上海200240

出　　处：《上海交通大学学报（医学版）》2020年第2期149-156,共8页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家重点研发计划(2017YFC1200202);上海交通大学科技创新专项资金(2020-RK11)。

摘　　要：由新型冠状病毒SARS-CoV-2(severe acute respiratory syndrome coronavirus 2)感染引起的疫情严重危害人类的生命安全,给社会造成巨大经济损失。目前,SARS-CoV-2从源头到感染人类过程中,哪些动物充当了传播媒介的角色尚未有定论。找到SARSCoV-2的动物宿主来源并切断传播途径是防控传染病的有效措施,对预防疫情再次发生、保障社会公共卫生安全具有重要意义。该文总结了SARS-CoV-2传播宿主的最新研究进展,并依据疫情事实推测SARS-CoV-2从蝙蝠到人类可能存在多个中间宿主。因此,在当前疫情防控乃至未来对新发传染病的防控中,基于同一健康创新理念加强人类医学-动物医学一体化防控体系建设至关重要。The epidemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has seriously compromised the security of human life as well as resulted in huge economic damages.Currently,it has yet to be determined that who are the intermediate animals of SARS-CoV-2 transmission during the transition from its origin to the human infection.In order to prevent and control infectious diseases,the effective measures are identifying the animals serving as the source and intermediate hosts and interrupting the transmission pathways.They are thus highly significant in the prevention of epidemic recurrence and the protection of public health security in society.This article summarizes the latest developments in the research on transmission hosts of SARS-CoV-2,and makes the inference of potentially-multiple transmission hosts based on the facts from current epidemic.Therefore,it is vital to strengthen the construction of the integrated prevention-and-control system(with human and veterinary medicines)using the innovative One Health approach during the current epidemic prevention and control stage,as well as emerging epidemic in the future.

关 键 词：新型冠状病毒 蝙蝠 中间宿主 同一健康 

分 类 号：Q939.4[生物学—微生物学]