甲状腺毒症周期性瘫痪与rs312691多态性关联的meta分析  

Association between rs312691 polymorphism and susceptibility to thyrotoxic periodic paralysis: a meta-analysis

作　　者：严同[1] 钟晓卫[1] 傅徐泉[1] 李华琦[1] 刘宜东[1] 黄晓飞[1] Yan Tong;Zhong Xiaowei;Fu Xuquan;Li Huaqi;Liu Yidong;Huang Xiaofei(Department of Endocrinology and Metabolism,the Third People's Hospital of Chengdu,Chengdu 610031,China)

机构地区：[1]成都市第三人民医院内分泌代谢病科

出　　处：《临床荟萃》2020年第2期123-128,共6页Clinical Focus

摘　　要：目的探讨KCNJ2基因下游rs312691多态性是否与甲状腺毒症周期性瘫痪(thyrotoxic periodic paralysis,TPP)发病有关。方法计算机检索PubMed、Embase、万方和中国知网数据库,收集关于rs312691单苷酸多态性(single nucleotide polymorphism,SNP)与TPP的病例对照研究文献。利用meta分析的方法评价该位点多态性与TPP之间的关系。结果共纳入7篇文献,共计961例患者,其中TPP组610例,对照组351例。Meta分析结果显示rs312691多态性与TPP的发生有关(OR=3.072,95%CI 2.590-3.643,P<0.01),剔除对照组不符合哈-温平衡后的亚组分析依然显示rs312691能增加TPP的风险(OR=2.804,95%CI 2.304-3.413,P<0.001)。结论rs312691单核苷酸多态性能增加发生TPP的风险。Objective To determine whether rs312691 polymorphism downstream of KCNJ2 confers susceptibility to thyrotoxic periodic paralysis(TPP).Methods Pubmed,Embase,Wanfang Chinese Periodical Database and China National Knowledge Infrastructure were systematically searched for control study related rs312691 polymorphism to thyrotoxic periodic paralysis.A meta-analysis was conducted on the association between the rs312691 polymorphism and TPP.Results A total of 7 comparison studies including 610 patients and 351 controls were considered in the meta-analysis.The meta-analysis showed a positive association between TPP and allele C of the rs312691 polymorphism in all study subjects(OR=3.072,95%CI 2.590-3.643,P<0.001).Stratification by Hardy-Weinberg equilibrium of the control group also identified significant positive association between this polymorphism and the susceptibility of TPP(OR=2.804,95%CI 2.304-3.413,P<0.001).Conclusion This meta-analysis shows that the rs312691 polymorphism confers susceptibility to thyrotoxic periodic paralysis.

关 键 词：甲状腺毒症 格雷夫斯病 低钾性周期性麻痹 rs312691 KCNJ2 

分 类 号：R581.5[医药卫生—内分泌]