羚羊清肺颗粒(濒危替代)药效学实验研究  

Experimental Study on Pharmacodynamics of Lingyang Qingfei Granule(羚羊清肺颗粒)(Endangered Substitute)

作　　者：李鹏飞 李亚琪 马全涛 王敬康 王敏[1] 冯鑫 王婷 肖环贤 王停 赵保胜 LI Peng-fei;LI Ya-qi;MA Quan-tao;WANG Jing-kang;WANG Min;FENG Xin;WANG Ting;XIAO Huan-xian;WANG Ting;ZHAO Bao-sheng(School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 102488,China;National Center for Drug Safety Evaluation and Monitoring,China Food and Drug Administration,National Key Laboratory of Non-clinical Safety Evaluation Research,Beijing 100176,China;Jiangxi Poly Pharmaceutical Co.,Ltd,Ganzhou Jiangxi 341900,China;Beijing Institute of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学中药学院,北京102488 [2]中国食品药品检定研究院国家药物安全评价监测中心、药物非临床安全评价研究北京市重点实验室,北京100176 [3]江西保利制药有限公司,江西赣州341900 [4]北京中医药大学北京中医药研究院,北京100029

出　　处：《中医药导报》2020年第4期24-29,共6页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(81773960);江西保利制药有限公司课题(横向课题)(2016110031007801),项目名称:羚羊清肺颗粒濒危药材替代补充申请临床前研究。

摘　　要：目的:评价羚羊清肺颗粒原方中羚羊角替换为山羊角后的解热、镇痛、祛痰、止咳以及对急性咽炎的治疗作用,并与羚羊清肺颗粒原方进行药效学比较,为羚羊清肺颗粒山羊角替代羚羊角提供实验依据。方法:通过内毒素致家兔发热实验,观察其解热作用;通过小鼠醋酸扭体实验,观察其镇痛作用;通过小鼠酚红排泌实验,观察其祛痰作用;通过枸橼酸诱发豚鼠咳嗽实验,观察其止咳作用;通过氨水致大鼠咽炎实验,观察其治疗急性咽炎作用。结果:羚羊清肺颗粒(濒危替代)可明显降低发热模型家兔体温,减少小鼠扭体次数,增加小鼠气管酚红排泌量,延长豚鼠咳嗽潜伏期,并显著降低豚鼠咳嗽次数;降低咽炎模型大鼠血白细胞数、中性粒细胞数以及淋巴细胞数,并能显著减轻大鼠气管组织炎性病变。结论:羚羊清肺颗粒(濒危替代)具有解热、镇痛、祛痰、止咳及治疗咽炎的药效学作用,山羊角可作为羚羊清肺颗粒原方中羚羊角替换的一种选择。Objective: To evaluate the antipyretic, analgesic, expectorant, antitussive and the therapeutic effect to acute pharyngitis after the replacement of antelope horn with goat horn in the original prescription of Lingyang Qingfei granules, and to compare the pharmacodynamics with the original prescription of Lingyang Qingfei granules, which provide experimental basis for the replacement of antelope horns with goat horns in Lingyang Qingfei granules. Methods: The endotoxin-induced fever in rabbits was used to observe its antipyretic effect;the mice acetic acid twist test was used to observe its analgesic effect;the mice phenol red excretion test was used to observe its expectorant effect;the citrate-induced guinea pigs cough experiment was used to observe its antitussive effect;the ammonia-induced pharyngitis experiment in rats was used to observe its effect on the treatment of acute pharyngitis. Results: Lingyang Qingfei granules(endangered substitute) can significantly reduce the body temperature of febrile model rabbits;reduce the number of twists in mice, increase the tracheal phenol red excretion in mice, prolong the cough latency of guinea pigs, and significantly reduce the number of coughs in guinea pigs;reduced the number of white blood cells, neutrophils, and lymphocytes in pharyngitis model rats, and significantly reduce the inflammatory lesions of tracheal tissue in rats. Conclusion: Lingyang Qingfei granules(endangered substitute) have the pharmacological effects of antipyretic, analgesic, expectorant, antitussive and cure pharyngitis of pharmacodynamic effect. The goat horn can be used as an alternative to the antelope horn in the original prescription of Lingyang Qingfei granules.

关 键 词：羚羊清肺颗粒 羚羊角 山羊角 濒危替代 解热 镇痛 祛痰 止咳 咽炎 家兔 小鼠 大鼠 

分 类 号：R285.5[医药卫生—中药学]