白介素-10、趋化因子受体7在甲状腺乳头状癌组织中的表达及其意义  

Expression of IL-10 and CXCR7 in papillary thyroid carcinoma tissues and their correlation with invasion and metastasis

作　　者：李丽燕[1] 王小洁[2] 王文文 胡一迪[4] Li Liyan;Wang Xiaojie;Wang Wenwen;Hu Yidi(Department of Pathology,Wenzhou Hospital of Traditional Chinese Medicine,Wenzhou 325000 China;Department of Ultrasound,Wenzhou Hospital of Traditional Chinese Medicine,Wenzhou 325000,China;Department of Nephrology,Wenzhou Integrated Traditional Chinese and Western Medicine Hospital,Wenzhou 325000,China;Department of Surgery,Wenzhou Hospital of Traditional Chinese Medicine,Wenzhou 325000,China)

机构地区：[1]温州市中医院病理科,325000 [2]温州市中医院超声科,325000 [3]温州市中西医结合医院肾内科,325000 [4]温州市中医院外科,325000

出　　处：《中华内分泌外科杂志》2020年第1期32-36,共5页Chinese Journal of Endocrine Surgery

基　　金：浙江省临床功能材料与诊疗器件工程技术研究中心开放基金(WIBEK181009)。

摘　　要：目的探讨白介素-10(interleukin-10,IL-10)、趋化因子受体7(chemokine receptor 7,CXCR7)在甲状腺乳头状癌(papillary thyroid carcinoma,PTC)组织中的表达及其与侵袭转移的相关性。方法选取2015年6月至2018年6月在温州市中医院外科进行甲状腺切除术PTC患者作为研究对象,获得符合纳入及排除标准的68例癌组织及其癌旁组织石蜡标本,同时选择同期进行甲状腺切除术32例甲状腺滤泡性腺瘤患者病理标本作为对照。将所得石蜡标本分为癌组织组、癌旁组织组及甲状腺滤泡性腺瘤组。通过免疫组化SP染色法观察不同组织中IL-10与CXCR7表达情况,同时将IL-10与CXCR7表达与肿瘤病理特征进行相关性分析。结果癌组织中IL-10及CXCR7阳性表达率明显高于癌旁组织及甲状腺滤泡性腺瘤组(88.24%&14.71%&0.00%,75.00%&32.35%&15.63%,P均<0.05)。68例PCT患者中IL-10高表达38例(55.88%),IL-10低表达30例(44.12%);CXCR7高表达32例(47.06%),CXCR7低表达36例(52.94%);IL-10表达与肿瘤多灶性、TNM分期、中央区淋巴结转移、中央区+侧颈部淋巴结转移、浸润程度及肿瘤最大径呈明显正相关(r=0.486、0.509、0.468、0.422、0.629、0.674,P均<0.05);CXCR7表达与肿瘤多灶性、TNM分期、中央区淋巴结转移、中央区+侧颈部淋巴结转移及浸润程度呈明显正相关(r=0.425、0.563、0.490、0.287、0.481,P均<0.05)。结论PTC患者癌组织中IL-10及CXCR7呈高表达状态,其中IL-10表达水平与肿瘤分化程度、TNM分期、中央区淋巴结转移、侧颈部淋巴结转移、浸润程度及肿瘤最大径密切相关,CXCR7表达水平与肿瘤分化程度、TNM分期、中央区淋巴结转移、侧颈部淋巴结转移及浸润程度有关,两者均可能参与肿瘤的发生、发展过程。Objective To investigate the expression of interleukin-10(IL-10)and chemokine receptor 7(CXCR7)in papillary thyroid carcinoma(PTC)tissues and their correlation with invasion and metastasis.Methods According to the inclusion and exclusion criteria,68 cases of cancer tissues(cancer tissue group)and para-cancer tissues(para-cancer tissue group)collected from PTC patients in Wenzhou Hospital of Traditional Chinese Medicine from Jun.2015 to Jun.2018 were selected.Meanwhile,pathological specimens from 32 cases of thyroid follicular adenoma patients(thyroid follicular adenoma group)undergoing thyroidectomy during the same period were also enrolled.Immunohistochemical SP staining was used to observe the expression of IL-10 and CXCR7 in different tissues,and the correlation between the expression of IL-10 and CXCR7 and the pathological characteristics of tumor was analyzed.Results The positive expression rates of IL-10 and CXCR7 in cancer tissues were significantly higher than those in para-cancer tissues and thyroid follicular adenoma group(88.24%vs.14.71%vs.0.00%,75.00%vs.32.35%vs.15.63%;P<0.05).Among 68 PCT patients,38(55.88%)had high expression of IL-10,30(44.12%)had low expression of IL-10,32(47.06%)had high expression of CXCR7,and 36(52.94%)had low expression of CXCR7.IL-10 expression was positively correlated with tumor multifocal,TNM stage,central lymphatic metastasis,central+cervical lymphatic metastasis,invasion degree and tumor maximum diameter(r=0.486,0.509,0.468,0.422,0.629,0.674,P<0.05).CXCR7 expression was positively correlated with tumor multifocal,TNM staging,central lymphatic metastasis,central+cervical lymphatic metastasis,and infiltration(r=0.425,0.563,0.490,0.287,0.481,P<0.05).Conclusions IL-10 and CXCR7 are highly expressed in cancer tissues of PTC patients,among which IL-10 expression level is closely related to tumor differentiation degree,TNM stage,cervical lymphatic metastasis,infiltration degree and tumor maximum diameter.CXCR7 is related to TNM stage,cervical lymphatic metastasis and infiltrati

关 键 词：IL-10 CXCR7 甲状腺乳头状癌 侵袭 中央区淋巴结转移 侧颈部淋巴结转移 

分 类 号：R653[医药卫生—外科学] R736.1[医药卫生—临床医学]