哺乳动物获能精子蛋白酪氨酸磷酸化研究进展  

Research Progress of Protien Tyrosine Phosphorylation of Capacitated Mammalian Sperm

作　　者：胡启蒙[1] 何群 何建云 李蒙玉 杨宇新 HU Qimeng;HE Qun;HE Jianyun;LI Mengyu;YANG Yuxin(Hebei Key Laboratory of Animal Diversity,College of Life Sciences,Langfang Normal University,Langfang,Hebei 065000)

机构地区：[1]廊坊师范学院生命科学学院河北省动物多样性重点实验室,河北廊坊065000

出　　处：《家畜生态学报》2020年第1期9-13,共5页Journal of Domestic Animal Ecology

基　　金：廊坊师范学院青年基金项目(LSLQ201601)。

摘　　要：哺乳动物成熟精子是一种高度分化的生殖细胞,"获能"后具有受精能力,其中酪氨酸磷酸化过程是获能过程中非常重要的环节,参与调控获能相关的顶体反应和超激活运动。精子获能分子机理研究有助于解决临床男性不育以及男性避孕问题,同时为牲畜体外人工授精技术应用提供理论支持。目前哺乳动物获能精子蛋白酪氨酸磷酸化的分子机制研究主要集中在信号通路、蛋白质种类鉴定、影响因素等方面。Mammalian mature sperm is a highly differentiated germ cell with fertilizing ability after "capacitation". The tyrosine phosphorylation process is a very important part of the capacitation process, and it is involved in regulating the acrosome response and supercapacitation related to capacitation. The research on the molecular mechanism of sperm capacitation helps to solve the problems of clinical male infertility and male contraception, and provides theoretical support for the application of in vitro artificial insemination technology for livestock. At present, the molecular mechanisms of tyrosine phosphorylation of capacitated sperm proteins in mammals are mainly focused on signal pathways, protein species identification, and influencing factors.

关 键 词：精子 酪氨酸磷酸化 调节因子 

分 类 号：S811.5[农业科学—畜牧学]