“面向中药绿色制造的特种膜技术与专属装备”的研究策略与实践--20余年中药膜科技研究与应用的回顾、反思与展望  

Strategies and practices on‘special type of membrane and membrane equipment for the green manufacturing of Traditional Chinese Medicine(TCM)’——a critical review and perspectives on the study and application of membrane technology in TCM production for the past two decades

作　　者：钟文蔚 李绍平 郭立玮[1,3,4] 陈顺权 袁海[1] 骆玉凤 ZHONG Wenwei;LI Shaoping;GUO Liwei;CHEN Shunquan;YUAN Hai;LUO Yufeng(Guangdong Key Laboratory of Membrane Materials and Membrane Separation,Guangzhou Institute of Advanced Technology,Guangzhou 511458,China;State Key Laboratory of Quality Research in Chinese Medicine,University of Macao,Macao,China;Jiangsu Botanical Medicine Refinement Engineering Research Center,Nanjing University of Chinese Medicine,Nanjing 210029,China;JIANGSU JIUWU Hi-Tech Co.,Ltd,Nanjing 210004,China;Three Agriculture Group(Guangdong)Co.,Ltd,Guangzhou 510000,China)

机构地区：[1]广东省膜材料与膜分离重点实验室,广州中国科学院先进技术研究所,广州511458 [2]澳门大学中药质量标准国家重点实验室,澳门 [3]南京中医药大学植物药深加工工程研究中心,南京210029 [4]江苏久吾高科技股份有限公司,南京210004 [5]中合三农(广东)集团有限公司,广州510000

出　　处：《膜科学与技术》2020年第1期360-366,共7页Membrane Science and Technology

基　　金：国家自然科学基金项目(30572374、30171161、30873449、81274096);国家科技部“十五”科技攻关计划项目(2004BA721A42);国家科技部“十一五”科技支撑计划项目(2006BAI09B07-03);国家科技部重点研发计划“中医药现代化研究”重点专项(2019YFC1711300);2017中国工程院咨询项目(2017-XZ-08);广州市科技项目(201904010054)。

摘　　要：回顾20余年来,课题组坚持“中药膜科技研究与应用”奋斗历程的基础上,结合成功申报“中医药现代化研究”重点专项2019年度项目的若干认知,对“基于特种膜的中药绿色制造技术与专属装备研究”进行了深入思考,提出独特的见解.“绿色制造”是一个综合考虑环境影响和资源消耗的现代制造模式,其宗旨:资源利用率最高,对环境负面影响最小,并使企业经济效益与社会效益协调优化.如何通过中药制药过程从中药物料获取尽可能完整的“天然组合化合库”,在临床取得原有汤剂应有的疗效并有所提高,是中药绿色制造所面临的主要科学问题.本文介绍了面向国家《中药新药注册分类》一类、二类与六类新药等多尺度目标产物制药技术需求,本团队业已开展的“面向中药绿色制造多尺度目标产物需求的新型膜材料、装备制备及分离机制”研究进展,主要为:(1)面向中药多元、整体药效物质获取的核孔膜改性方法与集群筛选机理研究;(2)面向小分子活性物质精准分离的规整纳埃级孔道膜研究等.This paper reviewed the important progresses in membrane technology for TCM production and the authors shared their perspectives on the special types of membrane and membrane equipment for the green manufacturing of TCM.Green manufacturing is a modern manufacturing trend where it takes environmental impact and consumption of resources into great account.Its goal is to achieve maximum efficiency in resources consumption and to minimize the environmental impact,along with the optimal social and economic benefits.The main scientific problems in membrane technology for TCM production are to maintain the integrity and completeness of Natural Combinatorial Chemical Libraries in the TCM feed and to improve the clinical effectiveness of the original TCM decoction.This paper also outlined the technological manufacturing requirements for multi-scaled target products for drugs identified as Classes 1,2 and 6.Our research group has made important progress in the area of novel membrane materials and specialized membrane equipment design,as well as the separation mechanism for TCM manufacturing with multi-scaled target products.The research work involves 2 major aspects,namely they are,approaches to post-modification on track-etched membrane for obtaining effective components with well-maintained integrity from TCM and the cluster-screening separation mechanism,and the mechanism of precise separation of obtaining effective components in TCM with small molecular weight via track-etched membranes with very narrow pore sizes.

关 键 词：中药绿色制造 特种膜 分离机制 质量标准 数据驱动 

分 类 号：TQ028.8[化学工程]