短肽型肠内营养制剂治疗小儿慢性腹泻的效果研究  

Study on the effect of short peptide enteral nutrition on children with chronic diarrhea

作　　者：刘永芳[1] 高中敏 许丽娟[1] 朱朝敏[1] 孔粼[1] LIU Yongfang;GAO Zhongmin;XU Lijuan;ZHU Chaomin;KONG Lin(Department of nutrition,Children′s Hospital Affiliated to Chongqing Medical University/Department of Gastroenterology,Children′s Hospital Affiliated to Chongqing Medical University/Ministry of Education Key Laboratory of Child Development and Disorders/China International Science and Technology Cooperation Base of Child Development and Critical Disorders/Chongqing Key Laboratory of Pediatrics,Chongqing 400014,China)

机构地区：[1]重庆医科大学附属儿童医院营养科/重庆医科大学附属儿童医院消化科/儿童发育疾病研究教育部重点实验室/儿童发育重大疾病国家国际科技合作基地/儿科学重庆市重点实验室,重庆400014

出　　处：《现代医药卫生》2020年第6期801-803,共3页Journal of Modern Medicine & Health

基　　金：重庆市科学技术局重点攻关项目(2011AB5038)。

摘　　要：目的 探讨短肽型肠内营养制剂(PBEN)治疗小儿慢性腹泻(CD)的临床疗效。方法 选取2017年1-12月重庆医科大学附属儿童医院住院的CD患儿50例,按随机数字表法分为研究组(25例,中途退出2例)和对照组(25例,中途退出4例)。研究组口服或经鼻胃管喂养PBEN,对照组给予母乳或普通婴幼儿饮食喂养。比较两组干预前后体重、贫血发生率及血清清蛋白(ALB)、总蛋白(TP)、血红蛋白(Hb)水平等变化情况。结果 两组干预后平均日增重、低体重儿发生率比较,差异均有统计学意义(P<0.05)。两组干预后ALB、TP、Hb水平均明显高于干预前,且贫血发生率明显低于干预前,差异均有统计学意义(P<0.05)。研究组干预后大便次数复常时间、大便性状复常时间、Hb水平及贫血发生率均明显优于对照组,差异均有统计学意义(P<0.05)。结论 采用PBEN治疗小儿CD能有效改善患儿营养状况,缩短临床症状恢复时间,值得临床推广使用。Objective To explore the clinical effect of short peptide enteral nutrition(PBEN)on children with chronic diarrhea(CD).Methods From January to December 2017,50 children with CD who were hospitalized in the Children′s Hospital Affiliated to Chongqing Medical University were divided into study group(25 cases,2 cases quitting midway)and control group(25 cases,4 cases quitting midway).The study group was fed PBEN orally or via nasogastric tube,while the control group was fed breast milk or ordinary infant diet.The changes of body weight,anemia incidence,serum albumin(ALB),total protein(TP),hemoglobin(Hb)were compared between the two groups before and after intervention.Results The incidence of average daily gain and low birth weight infants were compared between the two groups,the differences were statistically significant(P<0.05).The levels of ALB,TP and Hb in the two groups after intervention were significantly higher than those before intervention,and the incidence of anemia was significantly lower than that before intervention,the differences were statistically significant(P<0.05).The recovery time of stool frequency,the recovery time of stool character,the level of Hb and the incidence of anemia in the study group were significantly better than those in the control group,the differences were statistically significant(P<0.05).Conclusion PBEN can effectively improve the nutritional status of children with CD and shorten the recovery time of clinical symptoms,which is worthy of clinical application.

关 键 词：慢性腹泻 短肽型肠内营养制剂 营养不良 

分 类 号：R725.7[医药卫生—儿科]