自血穴位注射治疗慢性荨麻疹的Meta分析  

Meta-analysis on Autohemotherapy with Acupoint Injection for Chronic Urticaria

作　　者：赵健 张鑫 林培挺 胡桂兴[1] ZHAO Jian;ZHANG Xin;LIN Pei-ting;HU Gui-xing(Shenzhen Longgang People’s Hospital,Zhuhai People’s Hospital,Guangdong,Zhuhai 519000,China)

机构地区：[1]深圳市龙岗区人民医院,广东深圳518172 [2]珠海市人民医院,广东珠海519000

出　　处：《中国中医基础医学杂志》2019年第12期1726-1730,1748,共6页JOURNAL OF BASIC CHINESE MEDICINE

摘　　要：目的:评价自血穴位注射治疗慢性荨麻疹(CU)临床疗效与安全性。方法:计算机检索PubMed、CBM、VIP、CNKI、Wanfang数据库并辅以手工检索,时间从建库至2016年4月,收集自血穴位注射治疗CU的随机对照试验,对纳入文献进行资料提取和质量评估,并用Rev Man5. 3统计软件进行Meta分析。结果:纳入12个研究共944例患者,Meta分析结果显示自血穴位注射治疗CU的总有效率均优于西药组和针灸组,自血穴位注射治疗CU的愈显率均优于西药组和针灸组,自血穴位注射治疗CU的复发率显著低于对照组,仅有1项研究表明在治疗期间有不良反应,2项研究提到均未出现明显的不良反应,漏斗图显示纳入研究可能存在发表偏倚。结论:自血穴位注射的疗效优于单纯针灸或西药治疗,但纳入研究的样本量有限,以及大部分文献质量偏低,仍需设计合理、多中心、大样本的高质量临床随机对照研究以进一步验证。Objective:To assess the effectiveness and safety of autohemotherapy with acupoint injection in treating chronic urticarial(CU).Methods:Papers of randomized controlled trials of autohemotherapy with acupoint injection for CU in databases of PubMed,CBM,VIP,CNKI,Wanfang from the database-established year to April of 2016 were searched by electronic and manual retrieval.Data extracting and methodological quality of the included literatures was evaluated and analysed by using Review Manager 5.3 software.Results:12 trials involving 944 patients were included.The total effective rate in the autohemotherapy with acupoint injection were significantly better than western medicine and acupuncture therapy.The cure-remarkable-effectiveness rate in the autohemotherapy with acupoint injection were significantly better than western medicine and acupuncture therapy.The recurrence rate in the autohemotherapy with acupoint injection was significantly lower than control group.There was only one study reported the untoward effect,two studies no obvious adverse reactions.Conclusion:The curative effect of autohemotherapy with acupoint injection is superior to acupuncture and western medicine.But due to limited sample size,low quality of included literature,however,more rigorously designed,multicenter,large sample and high-quality RCTs are needed to enforce.

关 键 词：自血穴位注射 慢性荨麻疹 随机对照试验 META分析 

分 类 号：R758.274[医药卫生—皮肤病学与性病学]