利奈唑胺治疗耐多药肺结核的临床效果及其对血清Pgp、 GSTπ水平的影响  

Clinical effect of linezolid in the treatment of multi-drug resistant tuberculosis and its influences on serum Pgp and GSTπlevels

作　　者：何飞歌 吕海珍 HE Fei-ge;LYU Hai-zhen(Shaanxi Provinical Tuberculosis Prevention and Control Hospital/Shaanxi Fifth People's Hospital,Xi'an 710100,China)

机构地区：[1]陕西省结核病防治院/陕西省第五人民医院,陕西西安710100

出　　处：《临床医学研究与实践》2020年第6期30-32,共3页Clinical Research and Practice

摘　　要：目的探讨利奈唑胺治疗耐多药肺结核的临床效果及其对血清P-糖蛋白(Pgp)、谷胱甘肽S-转移酶-π(GSTπ)水平的影响。方法选取2017年8月至2018年8月本院收治的168例耐多药肺结核患者为研究对象,按随机数字表法将其分成对照组和观察组,每组84例。对照组给予常规抗菌药治疗,观察组在对照组基础上给予口服利奈唑胺。比较两组的临床疗效。结果治疗后,两组患者血清Pgp、GSTπ水平均明显降低,且观察组低于对照组(P<0.05)。观察组患者病灶吸收缩小、空洞闭合、临床症状改善、抗酸染色涂片阴性、痰菌PCR定量阴性人数均明显多于对照组(P<0.05)。观察组胃肠道反应、末梢神经炎发生率明显高于对照组(P<0.05);两组的血液系统不良反应、视力下降发生率无显著差异(P>0.05)。结论利奈唑胺能有效改善耐多药肺结核患者的临床症状,提高临床疗效,并降低血清Pgp、GSTπ水平,值得后续进行深入研究。Objective To investigate the clinical effect of linezolid in the treatment of multi-drug resistant tuberculosis and its influences on serum P-glycoprotein(Pgp)and glutathione S-transferase-π(GSTπ)levels.Methods A total of 168 patients with multi-drug resistant tuberculosis admitted in our hospital from August 2017 to August 2018 were selected as the study objects.The patients were divided into control group and observation group according to the random number table method,with 84 cases in each group.The control group was given conventional antibacterial therapy,and the observation group was given an oral administration of linezolid on the basis of the control group.The clinical efficacy of the two groups were compared.Results After treatment,serum Pgp and GSTπlevels of patients in both groups decreased significantly,and those in the observation group were lower than the control group(P<0.05).The numbers of patients with focal absorption reduction,cavity closure,improvement of clinical symptoms,negative acid fast smear and negative quantitative PCR of sputum bacteria in the observation group were significantly more than those in the control group(P<0.05).The incidences of gastrointestinal reactions and peripheral neuritis in the observation group were significantly higher than those in the control group(P<0.05);there were no significant differences in the incidences of adverse reactions of blood system and visual impairment between the two groups(P>0.05).Conclusion Linezolid can effectively ameliorate the clinical symptoms,improve the clinical efficacy,and reduce the levels of serum PGP and GSTπof patients with multi-drug resistant tuberculosis,which is worthy of further in-depth study.

关 键 词：利奈唑胺 耐多药肺结核 P-糖蛋白 谷胱甘肽S-转移酶-Π 

分 类 号：R521[医药卫生—内科学]