代谢综合征与前列腺癌临床进展的相关性研究  

Correlation between metabolic syndrome and clinical progression of prostate cancer

作　　者：陈楚杰[1] 张倩[2] 江东根 庞俊[1] 李骏[3] CHEN Chujie;ZHANG Qian;JIANG Donggen;PANG Jun;Li Jun(Department of Urology,Seventh Affiliated Hospital,Sun Yat-sen University,Shenzhen,Guangdong 518107,China;Department of Rehabilitation,Seventh Affiliated Hospital,Sun Yat-sen University,Shenzhen,Guangdong 518107,China;Department of Urology,Third Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong 510000,China)

机构地区：[1]中山大学附属第七医院泌尿外科,广东深圳518107 [2]中山大学附属第七医院康复医学科,广东深圳518107 [3]中山大学附属第三医院泌尿外科,广东广州510000

出　　处：《中国医学工程》2019年第11期7-10,共4页China Medical Engineering

基　　金：广东省医学科学技术研究基金项目(A2019555)

摘　　要：目的探讨代谢综合征(MS)及其各组分与前列腺癌恶性度的相关性。方法选取2008年1月1日至2018年4月1日在中山大学附属第三医院行前列腺癌根治术的前列腺癌患者391例为研究对象,回顾性分析其临床资料。结果391例患者中,合并MS 60例(15.3%),未合并MS 331例(84.7%)。合并MS患者的肿瘤恶性度指标(穿刺病理Gleason评分、术后病理Gleason评分、病理T分期和盆腔淋巴结转移)均明显高于未合并MS组(P<0.05)。在MS的各组分中,高血糖患者其术后病理Gleason评分、病理T分期和盆腔淋巴结转移又均明显高于正常血糖患者(P<0.05)。肥胖患者的术后病理Gleason评分高于不伴肥胖者(P<0.05)。结论在前列腺癌患者中,同时合并MS者并不多见,一旦合并MS,将会导致其肿瘤恶性度明显增加。在组成MS的各组分中,尤其是高血糖与前列腺癌进展密切相关。控制MS尤其是血糖的水平可能有利于前列腺癌的诊治。【Objective】To explore the relationship between metabolic syndrome(MS)and its components and the malignancy of prostate cancer.【Methods】A total of 391 patients with prostate cancer who underwent radical prostatectomy at the Third Affiliated Hospital of Sun Yat-sen University from January 1,2008 to April 1,2018 were enrolled.The clinical data were retrospectively analyzed.【Results】Of the 391 patients,60 were combined with MS(15.3%)and 331(84.7%)were not.The tumor malignancy index(Gleason score,postoperative pathological Gleason score,pathological T stage and pelvic lymph node metastasis)in patients with MS were significantly higher than those in the non-MS group(P<0.05).Among the components of MS,postoperative pathological Gleason score,pathological T stage and pelvic lymph node metastasis were significantly higher in patients with hyperglycemia than those with normal blood glucose(P<0.05).The postoperative pathological Gleason score of obese patients was higher than that of non-obese patients(P<0.05).【Conclusions】In patients with prostate cancer,it is rare to have MS at the same time.Once MS is combined,it will lead to a significant increase in tumor malignancy.Among the components that make up MS,especially hyperglycemia is closely related to prostate cancer progression.Controlling the level of MS,especially blood sugar,may be beneficial for the diagnosis and treatment of prostate cancer.

关 键 词：代谢综合征 前列腺癌 高血糖 肿瘤进展 

分 类 号：R587.1[医药卫生—内分泌]