金霉素软膏在预防造血干细胞移植患者肛周感染中的疗效观察  

Chlortetracycline ointment in prevention of perianal infection in patients undergoing hematopoietic stem cell transplantation

作　　者：蒋平芳[1] 葛永芹[1] 朱霞明[1] Jiang Pingfang;Ge Yongqin;Zhu Xiaming(Department of Hematology,The First Affiliated Hospital of Soochow University,Suzhou 215006,China)

机构地区：[1]苏州大学附属第一医院血液科,215006

出　　处：《国际医药卫生导报》2020年第4期481-483,共3页International Medicine and Health Guidance News

基　　金：苏州市护理学会护理科研项目(A2019-05)。

摘　　要：目的观察金霉素软膏在预防造血干细胞移植(HSCT)患者肛周感染中的疗效。方法选取2018年3月至2019年2月在本科接受治疗的120例HSCT患者作为研究对象,随机分为对照组和观察组各60例;对照组采用常规方法进行肛周护理,观察组在常规肛周护理的基础上,予每次坐浴后及便后清洁肛周,金霉素软膏涂抹;比较两组肛周感染发生率及治疗后两组患者肛周情况。结果观察组肛周感染的发生率(8.33%)明显低于对照组(21.66%),差异有统计学意义(P<0.05);两组感染者进行统计学比较,除体温外,观察组感染者肛周红肿发生率(20.00%)、疼痛程度(4.57±0.23)分、影响排便发生率(20.00%)、形成创面发生率(0.00%)均优于对照组[53.85%、(6.01±0.32)分、46.15%、23.08%](P<0.05);两组未感染者比较,观察组未感染者肛周红肿发生率(3.64%)和疼痛程度(2.32±0.12)分均低于对照组[14.89%、(3.21±0.11)分](P<0.05)。结论金霉素软膏用于造血干细胞移植患者中能明显降低移植后肛周感染的发生率,减轻肛周感染程度,具有良好的预防效果,值得临床借鉴。Objective To observe the effect of chlortetracycline ointment in the prevention of perianal infection in patients undergoing hematopoietic stem cell transplantation(HSCT).Methods 120 patients who underwent HSCT at our department from March,2018 to February,2019 were enrolled in the study,and were randomly divided into a control group and an observation group,with 60 cases in each group.The control group received routine perianal care;in addition,the observation group were perianally cleansed after bath and stool,and were varnished with chlortetracycline ointment.The incidences of perianal infection and the perianal conditions of the two groups after the treatment were compared.Results The incidence of perianal infection was significantly lower in the observation group than in the control group(8.33%vs.21.66%),with a statistical difference(P<0.05).There was no statistical difference in body temperature between these two groups(P>0.05).The incidences of perianal swelling,affected defecation,and wound formation as well as the pain degree were better in the infected patients in the observation group than in those in the control group[20.0%vs.53.85%,20.0%vs.46.15%,0.0%vs.23.08%,and(4.57±0.23)vs.(6.01±0.32);all P<0.05].The incidence of perianal swelling and the pain degree were lower in the uninfected patients in the observation group than in those in the control group[3.64%vs.14.89%and(2.32±0.12)vs.(3.21±0.11);both P<0.05].Conclusion Chlortetracycline ointment can significantly reduce the incidence of perianal infection in patients undergoing HSCT,reduce the degree of perianal infection,and has a good preventive effect,so it is worthy of clinical reference.

关 键 词：金霉素软膏 造血干细胞移植 肛周感染 

分 类 号：R473[医药卫生—护理学]