单纯疱疹病毒与天然免疫系统的相互作用的研究进展  

Progress on Interactions Between Herpes Simplex Virus and Innate Immunity

作　　者：牟唐维 李琦涵[1] MOU Tangwei;LI Qihan(Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Disease,Institute of medical Biology,Chinese Academy of medical Sciences and Peking Union Medical College,Kunming 650118,China)

机构地区：[1]中国医学科学院北京协和医学院医学生物学研究所,云南省重大传染病疫苗研发重点实验室,昆明650118

出　　处：《病毒学报》2020年第1期124-129,共6页Chinese Journal of Virology

基　　金：国家自然科学基金面上项目(项目号:31670173),题目:基于衣被蛋白UL7突变体分析的HSV1染色质化基因组DNA重聚/解构过程与转录调控的机理研究;中国医学科学院医学与健康科技创新工程项目(项目号:2016 12M 1 019),题目:创新型疫苗研究。

摘　　要：单纯疱疹病毒(Herpes simplex virus,HSV)包括1型和2型,属于人类疱疹病毒家族的α亚族,也是人类感染最常见的病原体之一,感染可导致多种疱疹性疾病,包括疱疹性眼炎及可引起失明的疱疹性角膜炎。HSV的致病机制与病毒和宿主天然免疫系统的相互作用密切相关,涉及到病毒逃逸干扰素反应,核转录因子κB(Nuclear factorκB,NF-κB)信号通路以及病毒与免疫细胞相互作用等多个环节。本文就近年来单纯疱疹病毒与天然免疫系统的相互作用的研究进展进行综述。Herpes simplex virus(HSV)type 1 and type 2 are α-herpesviruses of the Herpesviridae family,representing one of the most frequently encountered infections in humans. Its infection can cause a variety of herpetic diseases,including herpetic ophthalmia and herpetic keratitis. Pathogenesis of HSV is closely related to a panel of host innate immune responses,such as escape of interferon response,suppression of nuclear factor κB(NF-κB)signaling pathway,and interactions between virus and innate immune cells. This review focuses on the research progress on interactions between HSV and host innate immunity.

关 键 词：单纯疱疹病毒(HSV) 天然免疫 核转录因子κB(NF-κB) 

分 类 号：R373.9[医药卫生—病原生物学]