人博卡病毒编码蛋白功能研究  

Progress on the Function of Human Bocavirus Proteins

作　　者：德日 赵林清[2,1] DE Ri;ZHAO Linqing(Graduate School,Peking Union Medical College,Beijing 100730,China;Laboratory of Virology,Beijing Key Laboratory of Etiology of Viral Disease in Children,Capital Institute of Pediatrics,Beijing 100020,China)

机构地区：[1]北京协和医学院研究生院,北京100730 [2]首都儿科研究所病毒研究室,儿童病毒病病原学北京市重点实验室,北京100020

出　　处：《病毒学报》2020年第1期138-144,共7页Chinese Journal of Virology

基　　金：北京市自然科学基金面上项目(项目号:7192029),题目:不同基因型人博卡病毒的组织嗜性差异研究。

摘　　要：人博卡病毒(Human bocavirus,HBoV)是一类新发现的病毒,属于细小病毒科。至今己发现有4个基因型别(HBoV 1~4),不同基因型别的HBoV临床意义不同,有单一HBoV1感染致死的报道。但迄今为止,其复制机制、致病机理等尚不明确。HBoV基因组全长约为5.5kb,主要表达非结构蛋白NS1、NS2、NS3、NS4和NP1,以及结构蛋白VP1、VP2和VP3。本文旨在对近年来的HBoV各编码蛋白功能研究进展进行综述,并对HBoV未来可能的研究方向进行展望。Human bocavirus(HBoV),a novel virus found in 2005,belongs to Parvoviridae family. Four genotypes(HBoV 1-4)have been found untill now,and clinical characters of each genotype were different. A single HBoV1 infection was associated with several cases of death. But so far,the replication mechanism and pathogenic role of HBoV are still unclear. The HBoV genome is about 5. 5 kb in length and mainly expresses non-structural proteins NS1,NS2,NS3,NS4 and NP1,as well as structural proteins VP1,VP2 and VP3.This review aims to summarize the recent research progress on the function of HBoVs proteins,and to predict possible research directions of HBoVs.

关 键 词：人博卡病毒(HBoV) 结构蛋白 非结构蛋白 功能 

分 类 号：R373.9[医药卫生—病原生物学]