中缝背核5-羟色胺能神经通路功能研究进展  

The research of serotoninergic pathway function of dorsal raphe nucleus

作　　者：龙忠芳 刘程曦(综述) 喻田(审校) LONG Zhong-fang;LIU Cheng-xi(reviewing);YU Tian(checking)(Guizhou Key Laboratory of Anesthesia and Organ Protection,Zunyi Medical College,Zunyi 563000,Guizhou,China)

机构地区：[1]遵义医科大学贵州省麻醉与器官保护基础研究重点实验室,遵义563000

出　　处：《医学研究生学报》2020年第2期197-200,共4页Journal of Medical Postgraduates

基　　金：国家自然科学基金(81571026)。

摘　　要：中缝背核5-羟色胺(5-HT)能神经元投射到大脑的广泛区域,与许多生理过程及精神疾病的发生有关,如焦虑、奖赏、睡眠-觉醒、成瘾、抑郁症等,但5-HT能神经通路对上述众多不同生理或病理功能的调控机制尚未完全阐明。文章将从神经网络的角度出发,就目前已明确的中缝背核5-HT能相关神经通路参与调控焦虑、奖赏、睡眠-觉醒及药物成瘾进行综述。The 5-hydroxytryptamine(5-HT) neurons in the dorsal raphe nucleus(DRN) project to a wide area of the brain and are associated with many physiological processes and the occurrence of mental disorders, such as sleep-arousal, anxiety, reward, depression, neuroplasticity, et al.. However, the mechanisms of there functions on 5-HT neurons are unclear. This article start from neural network and review the relative signaling pathway of 5-hydroxytryptamine neurons in anxiety, reward and drug addiction.

关 键 词：中缝背核 5-羟色胺 焦虑 奖赏 药物成瘾 睡眠-觉醒 

分 类 号：R33[医药卫生—人体生理学]