纳米二氧化硅生物毒性的研究进展  

Recent advances in the biotoxicity of silica nanoparticles

作　　者：刘亚琴(综述) 曹济民(审校) LIU Ya-qin(reviewing);CAO Ji-min(checking)(Key Laboratory of Medical Electrophysiology of Ministry of Education,Institute of Cardiovascular Research,Southwest Medical University,Luzhou 646000,Sichuan,China)

机构地区：[1]西南医科大学心血管医学研究所,泸州646000

出　　处：《医学研究生学报》2020年第2期220-224,共5页Journal of Medical Postgraduates

摘　　要：纳米二氧化硅因为其独特的理化性质而被广泛应用于抗菌剂、分子探针、药物载体等多个领域中。由于纳米材料自身结构和功能的活跃性,其生物安全性近年来也成为毒理学研究的热点。文章综合国内外现有研究报道,从纳米二氧化硅在细胞水平和动物水平的毒性作用、影响毒性作用的因素和毒性作用机制进行综述,为纳米二氧化硅的研发、应用和生物安全性提供参考。Silica Nanoparticles(SiNPs) is widely used in many fields including antibacterial agent, molecular probe and drug delivery forits special physicochemical properties. Recently, the biosecurity of nano-materials has become a hot spot of research in toxicology due to special structure and functional activeness of nano-materials. This paper briefly summarized recent researchreports at home and abroadto review the toxicity of SiNPs on cells and animals, the factors for influencing the toxicity of SiNPs and the mechanisms underlying SiNPs biotoxicity, aiming to provide references for the development, application and biosecurity of SiNPs.

关 键 词：纳米二氧化硅 毒性 生物安全性 

分 类 号：Q7[生物学—分子生物学]