独活寄生汤治疗腰椎间盘突出症临床疗效的meta分析  

Meta-analysis of clinical efficacy of Duhuo Jisheng Decoction in the treatment of lumbar intervertebral disc herniation

作　　者：周峻 张刘波 熊振成 麻昊宁[1] 王延雷 孙岩 谭明生[1] 移平[1] 杨峰[1] 唐向盛[1] ZHOU Jun;ZHANG Liu-bo;XIONG Zhen-cheng;MA Hao-ning;WANG Yan-lei;SUN Yan;TAN Ming-Sheng;YI Ping;YANG Feng;TANG Xiang-sheng(Department of Spine Surgery,China-Japan Friendship Hospital, Beijing 100029 China;Graduate School,Beijing University of Chinese Medicine, Beijing 100029 China;Graduate School of Peking Union Medical College, Beijing, 100029 China)

机构地区：[1]中日友好医院骨科,北京100029 [2]北京中医药大学研究生院,北京100029 [3]北京协和医学院研究生院,北京100730

出　　处：《海南医学院学报》2020年第6期418-423,429,共7页Journal of Hainan Medical University

基　　金：国家自然基金面上项目(81873141);国家自然基金面上项目(81173423);首都临床特色应用研究项目(Z16110000516009)~~

摘　　要：目的:探讨独活寄生汤治疗腰椎间盘突出症的临床疗效。方法:通过计算机检索CNKI、VIP、Wan Fang Data、Pubmed、Cochrane Library、Medline complete和Embase数据库,以独活寄生汤加减联合西药治疗腰椎间盘突出症随机对照试验(RCT)为研究对象,检索时限均为建库至2019年7月20日,筛选文献,提取数据,利用Revman 5.3软件进行数据统计分析。结果:共纳入24篇文献,涉及1980例患者,Meta分析结果显示:与西药组相比,独活寄生汤加减组总有效率显著提高[(OR=5.26,95%CI(4.13,6.69),Z=13.47,P<0.00001)]和不良反应发生率显著降低[(OR=0.45,95%CI(0.23,0.87),Z=2.36,P=0.02)]。结论:独活寄生汤加减治疗腰椎间盘突出症具有显著的有效性和安全性,但本次研究纳入文献有限,且文献质量较低,尚需进行高质量、大样本的RCT进行深入的验证工作。Objective:To explore the clinical effect of Duhuo Jisheng Decoction in the treatment of lumbar disc herniation.Methods:Databases including CNKI,VIP,Wan Fang Data,Pubmed,Cochrane Library,Medline Complete and Embase were searched.The randomized controlled trial(RCT)of Duhuo Jisheng Decoction combined with western medicine in the treatment of lumbar intervertebral disc herniation was studied.The literature reviews were retrieved from the establishment of the database to July 20,2019.Data were extracted and analyzed by Revman 5.3 software.Results:Totally 24 literatures involving 1980 patients were included.Meta-analysis showed that the total effective rate of Duhuo Jisheng Decoction group was significantly higher[(OR=5.26,95%CI(4.13,6.69),Z=13.47,P<0.00001)]and the incidence of adverse reactions was significantly lower[(OR=0.45,95%CI(0.23,0.87),Z=2.36,P=0.00001)]than that of Western medicine group.Conclusion:Duhuo Jisheng Decoction is effective and safe in the treatment of lumbar intervertebral disc herniation.However,the literature included in this study is limited,and the quality of the literature is low.It is necessary to carry out in-depth verification of high-quality,large-sample RCT.

关 键 词：独活寄生汤 腰椎间盘突出症 META分析 

分 类 号：R274.9[医药卫生—中西医结合]