硫酸特布他林联合顺尔宁对小儿哮喘急性发作并大叶性肺炎的疗效分析  

Analysis of effect of terbutaline sulfate combined with shunning on acute attack of asthma complicated with lobar pneumonia in children

作　　者：邵昕[1] 钱俊[2] 蔡惠东[2] SHAO Xin;QIAN Jun;CAI Hui-dong(Department of Pediatrics, Yangzhou Friendship Hospital, Jiangsu Province, 225009 China;Department of Pediatric Respiration, Wuxi Children's Hospital, Jiangsu Province, 214023 China)

机构地区：[1]江苏省扬州友好医院儿科,江苏扬州225009 [2]江苏省无锡市儿童医院儿呼吸科,江苏无锡214023

出　　处：《海南医学院学报》2020年第6期463-466,471,共5页Journal of Hainan Medical University

基　　金：江苏省自然科学基金面上研究项目(BK20151112);江苏省医学创新团队(CXTDB2017016)~~

摘　　要：目的:探讨对小儿哮喘急性发作并大叶性肺炎采用硫酸特布他林联合顺尔宁治疗的疗效。方法:将150例哮喘急性发作并大叶性肺炎患儿作为受试者,随机分为常规组(75例)、联合组(75例),常规组给予常规治疗,研究组给予常规治疗+硫酸特布他林+顺尔宁。对比2组治疗前后肺功能、血清炎性因子变化,临床效果和安全性。结果:治疗后2组呼吸时间/吸气时间(Ti/Te)、达峰时间比(TPTEF/TE)、达峰容积比(VPEF/VE)、每千克潮气量(Vt/kg)均升高,且治疗后联合组均高于常规组,差异均具有统计学意义(P<0.05);治疗后两组血清肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)和白介素-8(IL-8)水平均明显下降,且治疗后联合组均低于常规组,差异均具有统计学意义(P<0.05);两组临床效果分布及比较,差异具有统计学意义(P<0.05);两组总有效率比较,联合组高于常规组,差异具有统计学意义(P<0.05);两组不良反应发生率比较,联合组稍高于常规组,差异无统计学意义(P>0.05)。结论:对哮喘急性发作并大叶性肺炎患儿在常规治疗的基础上给予硫酸特布他林联合顺尔宁可显著改善其肺功能和血清炎性因子,效果理想且安全。Objective:To explore the effect of terbutaline sulfate combined with shunning on acute attack of asthma complicated with lobar pneumonia in children.Methods:Totally 150 children with acute attack of asthma and lobar pneumonia were randomly divided into routine group(n=75)and combined group(n=75).The routine group was given routine treatment.The study group was treated with a combination treatment of routine therapy plus terbutaline sulfate and shunning.The changes of pulmonary function and serum inflammatory factors before and after treatment,clinical effect and safety were compared between the two groups.Results:Respiratory time/inspiratory time(Ti/Te),peak time ratio(TPTEF/TE),peak volume ratio(VPEF/VE),tidal volume per kilogram(Vt/kg)were increased in both groups after treatment(P<0.05),which in the combined group were higher than the routine group after treatment(P<0.05).After treatment,serum levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin-8(IL-8)in both groups decreased significantly(P<0.05),and those in the combined group were lower than those in the routine group(P<0.05).There was a significant difference in clinical effect distribution between the two groups(P<0.05).The total effective rate of the combined group was higher than that of the routine group(P<0.05).The incidence of adverse reactions in the combined group was slightly higher than that in the routine group(P>0.05).Conclusion:On the basis of routine treatment,terbutaline sulfate combined with shunning can significantly improve pulmonary function and serum inflammatory factors in children with acute attack of asthma and lobar pneumonia,with ideal effect and safe.

关 键 词：硫酸特布他林 顺尔宁 哮喘急性发作 大叶性肺炎 

分 类 号：R725.6[医药卫生—儿科]