超临界流体技术制备生物可降解聚合物/药物纳米微粒研究进展  

Research progress of biodegradable polymers/drug nanoparticles prepared by supercritical fluid technology

作　　者：詹世平 丁仕强[1,2] 王卫京 李鸣明[2] 赵启成[2] ZHAN Shiping;DING Shiqiang;WANG Weijing;LI Mingming;ZHAO Qicheng(College of Petrochemical Engineering,Lanzhou University of Technology,Lanzhou 730050,Gansu,China;College of Environmental and Chemical Engineering,Dalian University,Dalian 116622,Liaoning,China)

机构地区：[1]兰州理工大学石油化工学院,甘肃兰州730050 [2]大连大学环境与化学工程学院,辽宁大连116622

出　　处：《化工学报》2020年第3期923-935,共13页CIESC Journal

基　　金：国家自然科学基金项目(21676038)。

摘　　要：生物可降解聚合物/药物纳米微粒在药物靶向递送、有效成分封装和医疗诊断等领域具有突出的优势。超临界流体超细微粒制备技术具有绿色环保、制备方法种类多、粒径易调节和后续分离纯化容易等特点,得到了广泛的研究。为了得到满足使用要求的聚合物/药物纳米微粒,超临界流体制粒技术是有效的手段之一。论述了生物可降解聚合物纳米材料的特点和应用情况,简要介绍了超临界流体及特性,重点介绍了超临界溶液快速膨胀(RESS)、超临界抗溶剂沉淀(SAS)、超临界CO2辅助雾化(SAA)和超临界流体乳液萃取(SFEE)的工艺特点、制备方法、基本原理和研究进展,并对超临界流体技术制备聚合物/药物纳米微粒的发展方向进行了展望。Biodegradable polymers/drug nanoparticles have outstanding advantages in the fields of the drug targeted delivery, effective component encapsulation and medical diagnosis and so on. The nanoparticles preparation technologies from supercritical fluid have been widely studied because of its green environmental protection, many kinds of preparation methods, easy to adjust product quality according to the requirements of use, easy subsequent separation and purification, and so on. In order to obtain polymer/drug nanoparticles to meet the requirements,supercritical fluid granulation technology is one of the effective methods. The characteristics and applications of biodegradable polymer materials were discussed. Supercritical fluid and its characteristics were briefly introduced.The technological characteristics, preparing methods, basic principle and research progress on the rapid expansion of supercritical solution(RESS), supercritical anti-solvent precipitation(SAS), supercritical CO2 assisted atomization(SAA) and supercritical fluid emulsion extraction(SFEE) were mainly introduced. The development directions of polymer/drug nanoparticles prepared by supercritical fluid technology were prospected.

关 键 词：超临界流体 纳米微粒 聚合物 药物 

分 类 号：TB34[一般工业技术—材料科学与工程]