基于金纳米粒子及石墨烯量子点的四环素分子印迹电化学传感器研究  

An Electrochemical Molecularly Imprinted Sensor for Tetracycline Based on Gold Nanoparticles and Graphene Quantum Dots

作　　者：于壮壮 康天放[1] 鲁理平[1] YU Zhuang-zhuang;KANG Tian-fang;LU Li-ping(College of Environmental and Energy Engineering,Key Laboratory of Beijing on Regional Air Pollution Control,Beijing University of Technology,Beijing 100124,China)

机构地区：[1]北京工业大学区域大气复合污染防治北京市重点实验室环境与能源工程学院,北京100124

出　　处：《分析测试学报》2020年第2期182-189,共8页Journal of Instrumental Analysis

基　　金：北京市自然科学基金重点项目(B类)(KZ201110005006);国家教育部博士点基金博导类项目(20131103110011)。

摘　　要：该文以四环素为模板分子,4-氨基苯硫酚(4-ATP)为功能单体,采用循环伏安法在金纳米粒子和石墨烯量子点复合材料修饰的玻碳电极表面电聚合分子印迹膜,制备四环素(TC)分子印迹传感器(MIPs/GQDs-AuNPs/GCE),并通过循环伏安法(CV)、电化学交流阻抗法(EIS)和线性扫描伏安法(LSV)等研究了其电化学响应性能。结果表明,该传感器对四环素具有良好的电流响应。在最佳实验条件下,TC氧化峰电流值与其浓度在2.0×10^-8~3.0×10^-5 mol/L范围内呈良好的线性关系,相关系数为0.9994,检出限为1.5×10^-9 mol/L,加标回收率为97.9%~106%。该传感器稳定性好、响应灵敏、选择性高,具有良好的应用前景。In this study,a molecularly imprinted electrochemical sensor for tetracycline(TC),MIPs/GQDs-AuNPs/GCE was constructed,with TC as template molecule and 4-aminothiophenol(4-ATP)as functional monomer,by electrically polymerizing them both on the surface of glassy carbon electrode modified with gold nanoparticles and graphene quantum-dot composites through cyclic voltammetry(CV).CV,electrochemical impedance spectroscopy(EIS)and linear scan voltammetry(LSV)were used to investigate the electrochemical response of the molecularly imprinted sensor.Results showed that the sensor possessed a good current response to tetracycline.Under the best experimental conditions,there was a good linear relationship for the oxidation peak current of TC in the concentration range of 2.0×10^-8-3.0×10^-5 mol/L,with a correlation coefficient of 0.9994.The detection limit was 1.5×10^-9 mol/L.The recoveries were in the range of 97.9%-106.3%.With good stability,high sensitivity and selectivity,the sensor has a good prospect for application.

关 键 词：金纳米粒子 石墨烯量子点 四环素 分子印迹膜 电化学传感器 

分 类 号：O657.1[理学—分析化学]