响应面法优选山藿香涂膜剂成膜工艺条件  

Optimization of the Film Coating Agent Procedure for Teucrium viscidum Bl. by Response Surface Experiment

作　　者：舒洁倩[1] 梁盈军[2] 李子行[1] 袁娴[1] SHU Jie-qian;LIANG Ying-jun;LI Zi-hang;YUAN Xian(Guangdong Lingnan Institute of Technology,Guangzhou Guangdong 510663,China;Guangdong Hospital of TCM,Guangzhou Guangdong 510120,China)

机构地区：[1]广东岭南职业技术学院,广东广州510663 [2]广东省中医院,广东广州510120

出　　处：《中医药导报》2020年第2期13-15,19,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：2017广东省普通高校青年创新人才项目“岭南地产药材血见愁活性成分的药学研究及产品开发”(2017KQN CX124);广东岭南职业技术学院2017校级重点课题“山藿香止血镇痛抗炎活性成分及制剂研究”(KA201605)。

摘　　要：目的:优选山藿香涂膜剂成膜工艺条件。方法:以成膜时间、外观质量等作为评价指标,采用综合加权评分法,依据响应面(Box-Behnken)实验设计原理进行成膜材料及附加剂的筛选。结果:90%乙醇溶解的聚维酮K30+聚乙烯醇-124(2.1∶1)作成膜材料,添加甘油(3 mL/100 mL),含药微乳与空白涂膜剂配比(3∶1),制成的山藿香涂膜剂成膜时间较短且成膜性能好。结论:优选的成膜材料和附加剂可用于山藿香涂膜剂的制备。Objective: To optimize the procedure of the Teucrium viscidum Bl. film coating agent. Method:The film forming time and appearance quality were used as evaluation indexes, and the screening of film forming materials and additives were carried out according to the response surface experimental(Box-Behnken). Results: PVP K30+PVA-124(2.1∶1) dissolved by 90% ethanol were used as film forming material. And glycerin 3 mL/100 mL was added, ratio of emulsion and blank coating agent was(3∶1). The film forming time was shorter and the performance was better. Conclusion: The preferred film-forming material and additive can be used for the preparation of Teucrium viscidum Bl. film coating agent.

关 键 词：山藿香涂膜剂 响应面法 最佳工艺 

分 类 号：R283[医药卫生—中药学]