不同历史时期虚劳病组方用药规律分析  

Analysis on Medication Regularity of Consumptive Disease in Different Historical Periods

作　　者：许银坤 王一凡 李梓媛 李玥鑫 丁富平[1] 黄进[1] 张玉卓[1] 梁嘉颖 植耀锋 许世超 游幸 张进[1] XU Yin-kun;WANG Yi-fan;LI Zi-yuan;LI Yue-xin;DING Fu-ping;HUANG Jin;ZHANG Yu-zhuo;LIANG Jia-ying;ZHI Yao-feng;XU Shi-chao;YOU Xing;ZHANG Jin(Guangzhou University of Chinese Medicine,Guangzhou Guangdong 510006,China)

机构地区：[1]广州中医药大学,广东广州510006

出　　处：《中医药导报》2020年第2期101-105,共5页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：广东省自然科学基金项目(2018A030313632);广州中医药大学科研创新团队项目(2016KYTD10);广州中医药大学大学生创新创业训练项目(201910572168,S201910572113)。

摘　　要：目的:探究《中医方剂大辞典精选本》中隋唐及之前,宋元时期与明清及近代的虚劳病组方用药规律。方法:利用R语言数据挖掘软件对《中医方剂大词典精选本》中的方剂药物信息进行描述性分析(药物药类及药物性味与归经)、关联规则分析与聚类分析。结果:3个历史时期使用频率最高的药物分别为甘草、人参与熟地黄,使用药类居前的均包含补虚药、清热药、收涩药、利水渗湿药、温里药,累计频率均高于62.40%,药性以温性居多,药味都以甘、辛、苦为主,药物归经中归肾经药物的使用频率最高。关联规则与聚类分析共得出45个药对与药组,27个聚类方。结论:虚劳病的治疗在隋唐及之前取法经方以调和气血,宋元时期以补阳与补土为特点,明清及近代则重视阴精补益,呈现由气血并治,到倾向阴阳分治的特点。Objective: To study on the principles of formula composing and prescription of consumptive disease the Sui Tang Dynasties and before, Song and Yuan Dynasties, Ming and Qing Dynasties and after in Selected edition of Chinese medicine prescription dictionary. Method: The information of medicine in selected edition of Chinese medicine prescription dictionary was analyzed with descriptive analysis(drugs and pharmaceuticals, their characters, tastes and channel attribution), association rules analysis and cluster analysis with R software. Results: The most frequently medicine categories were Gancao(Radix Glycyrrhizae), Renshen(Panax Ginseng), Shudihuang(Rehmannia Glutinosa), and the top of medicine categories are medicines for tonifying deficiency, clearing heat, astringent, promoting urination and percolating dampness, thermo in the three historical period, the cumulative frequency is all higher than 62.40%. The medicinal properties are mostly warm, and the medicinal flavor is predominant in Gan, Xin and Bitter. Kidney drugs are the most frequently used medicines in meridian attribution. 45 medicine pairs and 27 cluster formulae were analyzed with association rules analysis and cluster analysis. Conclusion: In Sui and Tang Dynasties and before, the treatment of consumptive diseases was based on the method of regulating Qi and blood. In song and Yuan Dynasties, it was characterized by nourishing Yang and soil. In Ming and Qing Dynasties and modern times, it was emphasized on Nourishing Yin and essence. It shows the characteristics from the combination of Qi and blood to the separation of Yin and Yang.

关 键 词：虚劳 中医方剂大辞典精选本 数据挖掘 R语言 组方用药规律 历史时期 

分 类 号：R255.5[医药卫生—中医内科学]