雷公藤及其生物活性成分发挥缺血再灌注损伤保护作用的研究  

Protective effect of tripterygium wilfordii and its biological activity on ischemia-reperfusion injury

作　　者：孙凤娟 赵圣刚[2] 张祥宇[2] 江力勤[2] Sun Fengjuan;Zhao Shenggang;Zhang Xiangyu;Jiang Liqing(Huainan First People’s Hospital,Huainan 232000,China;Second Affiliated Hospital of Jiaxing University,Jiaxing 314000,China)

机构地区：[1]安徽省淮南市第一人民医院心内科,232000 [2]浙江嘉兴学院附属第二医院心内科,314000

出　　处：《心脑血管病防治》2020年第1期98-100,123,共4页CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT

基　　金：浙江省中医药科学研究基金计划项目(2015ZA204);浙江省医药卫生科技项目(2019ZD055);浙江省自然科学基金项目(LQ19H020003)。

摘　　要：缺血再灌注损伤多发生于外科手术、器官移植以及动脉介入治疗过程,其机制主要为细胞内氧化应激、钙超载、线粒体损伤导致的细胞能量代谢障碍及贯穿缺血再灌注损伤全过程的炎症反应等。雷公藤类药物已被多项研究表明,具有明显的抗炎、免疫抑制作用,发挥缺血再灌注损伤保护作用。本文简要介绍雷公藤对脑、肾、肝等器官的缺血再灌注损伤保护作用及机制。Ischemia-reperfusion injury mainly happens at surgery,organ transplantation and artery interventional treatment process.The main mechanism includes intracellular oxidative stress,calcium overload,the cell energy metabolism disorder caused by mitochondria damage and inflammatory reaction runs through the whole process of ischemia-reperfusion injury,etc.Several studies have shown that Tripterygium wilfordii drugs have obvious anti-inflammatory and immunosuppressive effect,and play a protective role in ischemia-reperfusion injury.This paper briefly introduces protective effect and mechanism of tripterygium wilfordii of ischemia-reperfusion injury on the brain,kidney,liver and other organs.

关 键 词：雷公藤 缺血再灌注损伤 炎症反应 钙超载 

分 类 号：R285.5[医药卫生—中药学]