原发性干燥综合征合并桥本甲状腺炎的临床特点  

Clinical analysis of primary sjogren's syndrome with Hashimoto thyroiditis

作　　者：仲彬 李杰 欣冰 王亚梅 上官海燕 陈晓倩 Zhong Bin;Li Jie;Xin Bin;Wang Yamei;Shangguan Haiyan;Chen Xiaoqian(Department of Endocrinology,Central Hospital of Nanjing,Nanjing 210018,China)

机构地区：[1]江苏南京市中心医院内分泌科,210018

出　　处：《中国临床保健杂志》2020年第2期213-216,共4页Chinese Journal of Clinical Healthcare

基　　金：江苏省南京市医学科技发展项目(YKK16256)。

摘　　要：目的分析原发性干燥综合征(pSS)合并桥本甲状腺炎(HT)的临床和实验室特点。方法选取pSS患者118例,根据是否合并HT分为pSS合并HT组(32例)和pSS未合并HT组(86例),比较两组的临床症状和检验指标的差异。结果118例pSS患者中27.1%合并HT,与未合并HT的pSS患者相比,合并HT的pSS患者口干、乏力症状的发生率增高(P<0.05),红细胞沉降率(ESR)、免疫球蛋白G(IgG)增高(P<0.05),类风湿因子(RF)阳性率增高(P<0.05),甲状腺肿大和浆膜腔积液发生率增高(P<0.05)。结论pSS患者中HT发病明显增多,对口干、乏力明显、甲状腺肿大、IgG升高的患者,要及时测定甲状腺功能及抗体。Objective To analyze the clinical and laboratory characteristics of primary sjogren's syndrome(pSS)patients with Hashimoto thyroiditis.Methods A total of 118 pSS patients were selected and divided into pSS combined HT group(32 cases)and pSS non-HT group(86 cases)according to whether combined with HT.The clinical symptoms and laboratory results of the two groups were compared.Results Among 118 pSS patients,32 patients(27.1%)had HT.Compared with pSS patients without HT,the incidence of dry mouth and weakness were increased in pSS patients with HT(P<0.05),ESR and immunoglobulin G(IgG)were increased in pSS patients with HT(P<0.05),RF positive rate was increased in pSS patients with HT(P<0.05),and the incidence of goiter and serosal effusion were increased in pSS patients with HT(P<0.05).Conclusions The incidence of HT is significantly increased in pSS patients,and for patients with dry mouth,obvious weakness,goiter and increased IgG,thyroid function and antibodies should be timely measured.

关 键 词：干燥综合征 桥本病 自身抗体 甲状腺功能减退 脏器受累 

分 类 号：R59[医药卫生—临床医学;医药卫生—内科学]