孕早期补充孕激素与妊娠期糖尿病发病率的相关性研究  

Correlation between Progesterone Supplementation in the Early Pregnancy and Incidence of Gestational Diabetes Mellitus

作　　者：齐冀 武红利[2] 齐全 蔡智慧[1] 李雅钗[1] QI Gi;WU Hong-li;QI Quan;CAI Zhi-hui;LI Ya-chai(Department of Gynecology,The Affiliated Hospital of Hebei University,Baoding,071000,China;Department of Obstetrics,The Affiliated Hospital of Hebei University,Baoding,071000,China;Graduate Faculty,Hebei University,Baoding,071000,China)

机构地区：[1]河北大学附属医院妇科,保定071000 [2]河北大学附属医院产科,保定071000 [3]河北大学研究生院,保定071000

出　　处：《神经药理学报》2019年第6期6-10,共5页Acta Neuropharmacologica

基　　金：河北省卫计委立项项目(No:20180703);河北大学附属医院青年基金项目(No:2017Q034)。

摘　　要：目的:探究孕早期孕激素的补充与妊娠期糖尿病(gestational diabetes mellitus,GDM)发病率的相关性。方法:选取663例孕早期低水平孕酮孕妇,424例作为观察组,补充孕激素,同期未补充孕激素的239例作为对照组。观察组根据补充孕激素的给药方式及剂量不同,分为口服组及肌注低、中、高剂量组,治疗结束后比较各组GDM发病率。结果:观察组GDM发病率高于对照组(P<0.05);口服组GDM发病率与对照组比较,差异无统计学意义(P>0.05);肌注组GDM发病率高于对照组(P<0.05);肌注组低、中、高剂量组GDM发病率依次升高(P<0.05)。结论:孕早期补充孕激素与GDM发病率相关;口服给药对GDM发病率无明显影响,肌注给药增加GDM发病率,且呈剂量依赖性。Objective:To explore the correlation between progestogen supplementation in early pregnancy and incidence of gestational diabetes mellitus(GDM). Methods:663 cases of low-level progesterone pregnant women in early pregnancy were selected,424 cases were supplemented with progesterone as the observation group,239 cases were not supplemented with progesterone at the same time as the control group. Pregnant women in the observation group were divided into oral group and intramuscular group with low dose,medium dose and high dose according to different administration methods and doses. The incidence of GDM in each group was compared after treatment. Results:The incidence of GDM in the observation group was higher than that in the control group(P<0.05);there was no significant difference in the incidence of GDM between the oral group and the control group(P>0.05);the incidence of GDM in the intramuscular injection group was higher than that in the control group(P<0.05);the incidenceof GDM in the low,medium and high dose groups increased in turn(P<0.05). Conclusion:Supplement of progesterone in early pregnancy is associated with the incidence of GDM. Oral administration has no significant effect on the incidence of GDM. Intramuscular administration increases the incidence of GDM in a dose-dependent manner.

关 键 词：血浆孕酮 外源性孕激素 妊娠期糖尿病 糖耐量实验 

分 类 号：R969[医药卫生—药理学]