乙肝后肝硬化与代谢综合征的相关性分析  

Correlation between liver cirrhosis and metabolic syndrome after Hepatitis B

作　　者：沈皓[1] 潘晓燕[1] 康杰[1] 董志敏[1] 胡建平[1] 武曼群[1] Shen Hao;Pan Xiaoyan;Kang Jie;Dong Zhimin;Hu Jianping;Wu Manqun(Department of Gastroenterology,Yinchuan No.1 People's Hospital,Yinchuan,Ningxia 750001,China)

机构地区：[1]银川市第一人民医院消化内科,宁夏银川750001

出　　处：《医药前沿》2020年第2期23-25,共3页Journal of Frontiers of Medicine

基　　金：宁夏医科大学科学研究基金资助项目;项目编号:XY2017085。

摘　　要：目的:通过Logistic分析乙肝后肝硬化与代谢综合征之间的相关性,对合并代谢综合征(MS)的乙肝患者,进行更好的预防和延缓肝硬化的发展,同时在临床工作中从治疗和预防代谢综合征的角度考虑和辅助预防肝硬化,为乙肝后肝硬化的治疗和预防提供一个新的思路。方法:对216例肝硬化患者及200例慢乙肝患者的FPG、TG、TC、HDL—C、LDL—C、UA、BMI、MBP、HBV-DNA进行比对分析。结果:216例HBV后肝硬化的患者合并代谢综合征者占40%,没有肝硬化的HBV患者中,患代谢综合征的仅占12%两组对比,差异显著(P<0.001)。代谢综合征可能是发生肝硬化的独立风险因素[比值比(OR)为1.864,95%可信区间(CI)为0.987-0.989]。结论:对于慢性乙型肝炎患者,代谢综合征是肝硬化的独立风险因素。Objective To study the correlation between HBV-related Hepatic Cirrhosis and metabolic syndrome by logistic analysis,to prevent and delay the development of Hepatitis B cirrhosis in patients with metabolic syndrome,and to assist the prevention of Hepatitis B cirrhosis from the perspective of treatment and prevention of metabolic syndrome,provide a new way in treatment and prevention of HBV-related Hepatic Cirrhosis.Methods FPG,TG,TC,HDL-C,LDL-C,UA,BMI,MBP and HBV-DNA were analyzed.In 216 patients with HBV-related Hepatic Cirrhosis and 200 patients with chronic Hepatitis B.Results Among 216 patients with HBV-related Hepatic Cirrhosis,40%had metabolic syndrome,while only 12%had metabolic syndrome(MS)without cirrhosis(P<0.001).Corrected,metabolic syndrome was an independent factor associated with possible cirrhosis[O>was 1.864,95%confidence interval(CI)was 1.1-2.6].Conclusion Metabolic syndrome is an independent risk factor for cirrhosis in patients with chronic Hepatitis B.

关 键 词：慢性乙型病毒性肝炎 乙肝后肝硬化 代谢综合征 

分 类 号：R512.62[医药卫生—内科学]