睾丸及附睾穿刺行ICSI治疗梗阻性无精子症的结局  

The outcome of ICSI in the treatment of obstructive azoospermia with TESE and PESA

作　　者：陈从良 赵永平[2] 徐小明 蔡杰 刘彩萍 Chen Congliang;Zhao Yongping;Xu Xiaoming;Cai Jie;Liu Caiping(Beijing Perfect Family Hospital,Beijing,100034,China;Peking University People's Hospital,Beijing,100035,China)

机构地区：[1]北京家圆医院,北京100034 [2]北京大学人民医院,北京100035

出　　处：《当代医学》2020年第9期16-18,共3页Contemporary Medicine

摘　　要：目的比较睾丸取精术(TESE)和经皮附睾穿刺取精术(PESA)获得精子行卵胞浆内单精子注射(ICSI)治疗梗阻性无精子症的妊娠结局。方法回顾性分析2015年1月至2018年1月因梗阻性无精子症在本中心行ICSI助孕的54对夫妇(104个周期),分为附睾精子组(PESA组,n=23)和睾丸精子组(TESE组,n=31),比较两组的2PN受精率、可移植胚胎率、优质胚胎率、临床妊娠率、流产率等。结果TESE组可移植胚胎率明显高于PESA组(P<0.05),两组2PN卵裂率、受精率、优质胚胎率、临床妊娠率、活产率、流产率比较差异无统计学意义。结论虽然睾丸精子与附睾精子处于精子成熟过程的不同阶段,但对于梗阻性无精子症而言,TESE和PESA取精行ICSI治疗后,其临床结局无明显差异。Objective To compare the pregnancy outcomes of intracytoplasmic sperm injection(ICSI)of in the treatment of obstructive azoospermia by testicular sperm extraction(TESE)and percutaneous epididymal sperm aspiration(PESA).Methods From January 2015 to January 2018,54 couples of ICSI assisted pregnancy(104 cycles)in our center were analyzed retrospectively.They were divided into epididymal sperm group(PESA group,n=23)and testicular sperm group(TESE group,n=31).2PN fertilizing rate,transplantable embryo rate,high quality embryo rate,clinical pregnancy rate and abortion rate were compared between the two groups.Results The rate of transplantable embryos in TESE group was significantly higher than that in PESA group(P<0.05).There was no significant difference in 2PN cleavage rate,fertilizing rate,high quality embryo rate,clinical pregnancy rate,live rate and abortion rate between the two groups.Conclusion Although testicular sperm and epididymal sperm are in different stages of sperm maturation,there is no significant difference in clinical outcome between TESE and PESA after ICSI treatment for obstructive azoospermia.

关 键 词：梗阻性无精子症 睾丸取精术 经皮附睾穿刺取精术 临床妊娠率 卵胞浆内单精子注射 

分 类 号：R698.2[医药卫生—泌尿科学]